[Metabolism of vitamin B1 and its di- and triphosphate esters in experimental allergic encephalomyelitis].

Biological significance of thiamin in development of experimental allergic encephalomyelitis has been elucidated. It has been shown that at the late preclinical stage of the disease thiamine metabolism is predominantly directed towards the maintaining of cellular metabolic homeostasis, whereas at the stage of clinical symptoms the anabolic process gives way to catabolic decomposition. Among tested thiamine phosphates the triphosphate ester is the most informative parameter in demyelinizing processes.

[Fluorescent ophthalmochromoscopy in the diagnosis of multiple sclerosis].

The authors applied a method of fluorescent ophthalmochromoscopy for the characteristics of the optic nerve in 61 patients with disseminated sclerosis. All the patients had undergone a comprehensive ophthalmological examination. A clinical characteristic is given for the initial period of disseminated sclerosis (I group of patients) and for the florid picture (II group).

[Experience with the use of cyclophosphamide in multiple sclerosis].

The effect of cyclophosphamid on the development of disseminated sclerosis was studied in 85 patients. For this purpose the authors used a special scale for the assessment of neurological expressions of the disease and the remote results of treatment. The effectiveness depended mainly on the degree of severity.