[Change in the fatty acid composition of the brain and spinal cord lipids in white rats during supercooling and adaptation].

Adaptation to supercooling did not affect distinctly the fatty acid composition of brain total lipids but altered the fatty acid composition of phospholipids: amount of unsaturated acids was increased mainly due to an increase in concentrations of oleic, arachidonic and docosapentaenic acids. The same alterations occurred in brain phospholipids of the animals after a single cooling. The content of unsaturated fatty acids (mono-, dienic and polyenic acids) was distinctly decreased in spinal cord lipids during adaptation to supercooling.

[Amide groups of brain and spinal proteins in acute and chronic alcohol intoxication].

Acute and chronic alcohol intoxication causes a considerable deamidation of central nervous system proteins which is most pronounced in the spinal cord. There occurs rearrangement in the amide bonds lability and in the ratio of easy-hydrolyzable and strongly bound amide groups. The metabolic response to the single administration of ethanol is disturbed.

[Brain and spinal cord nitrogen metabolism in chronic alcoholism following strenuous physical exertion].

Development of the fatigue state in rats, subjected to prolonged alcohol intoxication, after swimming with might led to dissimilar alterations in the system of ammonia formation and binding in brain and spinal cord as compared with control animals under the same conditions of loading. Within the first minutes of the heavy loading the faster and more distinct accumulation of ammonia was observed, then the rapid exhaustion of the reaction occurred and the ammonia production was markedly decreased in the state of fatigue. Impairments in brain protein deamidation and decrease in content of urea were found.

[Aspartate aminotransferase activity in the brain and spinal cord in acute and chronic alcoholic intoxication].

Resynthesis of aspartate via glutamate was decreased 6-8-fold in rat brain spinal cord tissues due to distinct inhibition of aspartate aminotransferase in acute alcohol intoxication. Consumption of glutamic acid was distinctly increased 1.5-2-fold in tissues of the central nervous system but its metabolism was altered.

[Change in the content of adenine nucleotides and creatine phosphate and in the activity of creatine kinase in the large intestine mucosa in chronic enterocolitis in relation to the severity of the disease].

Content of ATP, ADP, AMP, phosphocreatine and activity of creatine kinase were estimated in homogenates of biopsy material obtained from large intestine mucose of patients with chronic enterocolitis and of healthy persons. Impairments were observed in interrelations and transformations of adenine nucleotides and in creatine kinase reactions. Decrease in content of total adenine nucleotides and of ATP correlated with the degree of the disease severity.

[Characteristics of the central nervous system metabolism reaction to stress in acute alcoholic intoxication].

In a state of acute alcohol intoxication metabolic response on the stress of the central nervous system was distinctly altered in rats (formation and binding of ammonia in brain and medulla spinalis). The following effects were observed: deamidation of brain proteins was impaired, the intensity of ammonia formation was decreased, content of urea decreased and dynamics of gamma aminobutyric acid, dicarbonic amino acids and their amides was altered.

[Influence of adaptation to supercooling on the fatty acid composition of rat tissue lipids].

Adaptation to supercooling produces a considerable effect on composition and quantitative content of certain fatty acids in all the studied tissues. In lipids of the myocardium and skeletal muscles adaptation causes an increase in the content of unsaturated fatty acids in particular of polyenic ones. In lipids of the lungs, vice versa, the content of saturated fatty acids increases, chiefly due to palmitic acids.