[Clinical-morphological changes of venous system of the heart in dependence on the stage of chronic heart failure].

Cardiac venous system (CVS) in chronic heart failure (CHF) undergoes whole row of morpho functional changes, but investigations of CVS are practically absent. We studied CVS of patients with Doppler echocardiography and magnetic computer tomography of the heart. The state of peripheral venous system was assessed by measurement of peripheral venous pressure (PVP) with Waldman apparatus.

[Modification of coronary sinus in patients with chronic cardiac insufficiency].

Both venous and arterial beds undergo a number of morphofunctional changes in patients with cardiovascular pathology, but they rarely attract attention of researchers. The available data indicate that the cardiac venous system (CVS) plays an important role in the development of chronic cardiac insufficiency (CCI) and dictate the necessity of its in-depth studies. We examined CVS in 160 patients by Doppler echo-CG and in 41 ones by spiral CT.

[The peripheral and intracardiac venous system of the heart in chronic heart failure].

Aim: To evaluate the cardiac venous system (CVS) and its changes in chronic heart failure (CHF), by applying noninvasive studies.

Subjects And Methods: CVS was studied by Doppler echocardiography in 160 patients and by multispiral computed tomography (MSCT) in 41. For evaluation of the peripheral venous system (PVS), a Wildman apparatus was used to measure peripheral venous pressure.

[Effects of endotheline and nitric oxide on vascular tonicity in patients with chronic cardiac failure].

Aim: To examine effects of endotheline-1 (ET-1) and nitric oxide (NO) on endothelium-dependent mechanisms of vascular tonicity regulation in patients with chronic cardiac failure (CCF) of FC I-IV (NYHA).

Material And Methods: Vascular reactions of 94 patients with CCF of FC I-IV were examined according to D.S.

[Experience in treating patients with cardiovascular diseases by means of adaptation to periodic barochamber hypoxia].

Adaptation to periodic hypoxia (decompression 490 mm Hg) in a multiplace medical pressure chamber of patients with hypertension, cardial neurocirculatory asthenia, coronary heart disease produced a persistent hypotensive effect with improvement of central and peripheral hemodynamics, oxygen homeostasis, electrolyte balance of blood. In patients with neurocirculatory asthenia associated with ventricular and supraventricular extrasystole positive hemodynamic changes accompanied a persistent antiarrhythmic effect. In addition to the latter, CHD patients experienced improvement in myocardial contractility.

[The use of the delayed-action form of korinfar in arterial hypertension, stenocardia and hypertrophic cardiomyopathy].

Corinfar-retard (CR) was tried in 146 patients, the acute test was performed in 26 cases. The findings confirm antihypertensive activity of the drug, reduced frequency of sharp changes in blood pressure and of hypertensive crises, side effects, its ability to diminish platelet aggregation. As for coronary heart disease.

[The nondrug treatment of hypertension patients by their adaptation to periodic hypoxia in a barochamber].

Patients with essential hypertension were exposed to periodic hypoxia in a pressure chamber. It is shown that adaptation to periodic hypoxia results in improvement of general condition of patients who exhibited a decline in blood pressure, minute blood volume, serum sodium concentrations as well as better microcirculation and tissue oxygen tension. Reduced concentrations of total serum cholesterol and atherogenic index were achieved in hypercholesterolemia patients.

[Loss of creatine in the body in cardiac insufficiency and prevention of this pathology with alpha-tocopherol].

Peculiarities of creatinemia and creatinurea have been studied in patients with different stages of the heart failure. Administration of alpha-tocopherol, an antioxidant, promotes normalization of these changes. Antioxidants are discussed in the aspect of their possibility prevent the creatine loss by the heart and skeletal muscles in case of the heart failure.

[Changes in antioxidative enzyme activity in patients with chronic heart failure].

Primary (dienic conjugates) and secondary (malonic dialdehyde) products of plasma lipid peroxidation were measured and the activity of antioxidative enzymes (glutathione peroxidase and superoxide dismutase) in erythrocytes was determined in 96 patients with chronic heart failure due to ischemic heart disease and rheumatic heart disease. Heart failure was found to show elevated plasma lipid peroxidation product levels, mostly in Stages I and IIA. Whereas in Stage IIB, the product levels became lower and in Stage III, they reached the control values.

[Mathematical approach to the problem of early diagnosis in heart failure].

A tool set for early detection of heart failure (HF) and its criteria for mass population survey in the polyclinic setting was developed. A two-stage screening programme was carried out. At the first stage, patients with cardiac abnormalities were detected.

[Effect of calcium on the diastolic phases in healthy persons and in patients with cardiac insufficiency].

Variations in the duration of diastolic phases under acute calcium loading were studied in normal subjects and patients with heart failure, using left ventricular apexcardiography (ACG). Certain changes in diastolic phases were revealed in patients with heart failure as compared to normal subjects, which corresponded to the severity of heart failure. The phase of isometric relaxation as well as those of rapid and slow filling showed the most dynamic variation.