Publications by authors named "Ia I Khadzhaĭ"

The analgesic effect, acute toxicity and pharmacokinetics of lysine acetylsalicylate (LAS), a water-soluble salt of acetylsalicylic acid (ASA) were studied as compared with a 50% solution of analgin and a 4% solution of amidopyrine at intramuscular administration and ASA administered intragastrically. During inflammation-induced pain in rats LAS exerts a pronounced analgesic effect exceeding the activity of other agents. LD50 of LAS was similar to that of analgin and ASA.

View Article and Find Full Text PDF

A nonsteroidal anti-inflammatory agent khlotazol administered to rats in doses of 40-80 mg/kg for 5 days stimulated synthesis of IgM- and IgG-antibodies to ram erythrocytes and increased the number of antibody-forming cells (AFC) and rosette-forming cells (RFC) in the spleen. When the doses were increased to 160-320 mg/kg, the stimulating effect of the drug on the production of hemagglutinins retained but dose-dependent inhibition of the number of AFC and RFC was found. When administered in a dose of 80 mg/kg khlotazol markedly activated the reaction of hypersensitivity of delayed type induced by ram erythrocytes.

View Article and Find Full Text PDF

By using methods of fluorescent and spine (electron paramagnetic resonance) probes it was shown that cardiac glycosides (digoxin, digitoxin, convallatoxin, corelborine and strophanthin) effectively interact with biomembrane lipids enhancing conformational motility of lipids and cause additional binding of calcium ions with the membrane.

View Article and Find Full Text PDF

Lysine acetylsalicylate, a water-soluble salt of acetylsalicylic acid, administered intravenously to rabbits (15 and 100 mg/kg) and also in vitro (2-10 mg/ml) produced antiaggregational and anticoagulant effects pertaining to acetylsalicylic acid. Pharmacokinetics of acetylsalicylic acid injected intravenously to rabbits in the form of lysine acetylsalicylate is formalized by a biexponential equation for a two-compartment model. The main pharmacokinetic constants of acetylsalicylic acid in these experiments were found to be similar to those in humans.

View Article and Find Full Text PDF

According to the rheo- and photoplethysmography data, ethyl-3,5,6-tri-O-benzyl-D-glucofuranoside (glivenol, tribenol; 25,250 and 4000 mg/kg i.p.) markedly increases the blood content in hind limbs of rabbits, displaying a tendency towards a decrease in systemic arterial pressure and negligibly raises the body temperature when given in maximal doses, without affecting cardiac activity and respiration.

View Article and Find Full Text PDF

In isadrin-induced myocarditis, the rat heart shows an increase in the activity of acid phosphatase, glucose-6-phosphate dehydrogenase. The heart weight also rises, whereas ATPase activity and magnesium content fall. Under these conditions strophanthin produces a marked decrease in acid phosphatase activity, stimulates the activity of glucoso-6-phosphate dehydrogenase, and demonstrates a tendency to increasing the activity of ATP-splitting enzymes, to reducing the activity of ATP-synthetase, and to the recovery of the magnesium content.

View Article and Find Full Text PDF

Experiments "in vitro" have brought evidence that butadion, escinol, esculetin, glyvenol, rutin, escin and the summary flavor noid preparation are capable of stabilizing erythrocytes membranes with the cells subjected to hypotonic hemolysis. Depending upon optimal concentrations the activity of the substances was within the range of 10(-3) to 10(-8). As concerns the intensity of the effect in the optimal concentration (10(-5) M), that corresponds to the one built up in the blood of patients given the therapeutic dose of the drug, the action of glyvenol was 1.

View Article and Find Full Text PDF