[Effectiveness of combined use of a lipid peroxidation inhibitor and a lymphatic drainage stimulant in intensive care of acute myocardial infarct].

The efficacy of intensive care for acute myocardial infarction making use of mannitol and vitamin E was under study. The results evidence a marked clinical effect of both the drugs. ECG demonstrates that in the majority of cases the necrotic process is arrested and no grave complications develop after such treatment, and the ECG parameters normalize.

[Stimulation of the lymphatic drainage in intensive care of acute myocardial infarct].

Under study was reogluman efficacy in the acute period of myocardial infarction. Timely administration of the drug to myocardial infarction patients was conductive to reduction of the duration and intensity of the painful syndrome, was associated with a reduction and even disappearance of congestion in the lungs within the first 2 days. These changes were paralleled by a more rapid normalization of the activities of all the blood serum lysosomal enzymes in the patients treated with reogluman as against the reference patients.

[Use of rheogluman in the acute period of myocardial infarction].

The efficacy of rheogluman was evaluated in 55 patients with acute myocardial infarction. ECG mapping recordings in 35 leads showed that an earlier positive dynamics in sigma ST, sigma Q, and sigma R was significantly observed in patients treated with rheogluman than in untreated patients. These data indirectly indicated a reduction in the ++peri-infarct zone in the acute period of myocardial infarction.

[The efficacy of the combined use of a lipid peroxidation inhibitor and a stimulator of the lymphatic drainage of the heart in the treatment of the acute period of myocardial infarction].

The effect of combined use of mannitol and alpha-tocopherol on the course and outcome of acute myocardial infarction has been studied. The results have shown that these drugs have a marked clinical effect. The ECG findings show that in the majority of cases the drugs prevented further development of necrotic process and the onset of life-threatening complications and accelerated normalization of the ECG parameters.

[Effect of lymph-stimulating drugs on the clinical manifestations and parameters of lipid metabolism in patients with post-infarction cardiosclerosis and angina pectoris].

As many as 64 patients with coronary heart disease (CHD) were examined. They were divided into 3 groups: (1) control subjects; (2) patients on supplementary rheogluman and (3) those on supplementary haemodesum (neocompensan). Their status was assessed from the frequency and intensity of anginal attacks, the magnitude of changes in lipid metabolic parameters prior to and following the therapy.

[Effect of heparin, obsidan and rheogluman on lymph coagulating activity and flow rate in acute myocardial infarction].

Experiments were conducted on dogs to study the effect of heparin, obsidan, and rheogluman on the rate of lymph flow from the thoracic duct and the lymph coagulation potential in acute myocardial infarction. Rheoglumin produced the most marked lymph stimulating effect. The effect of heparin and partly that of rheogluman on lymph coagulability is mediated.

[The effect of pharmacological agents on the rate of lymph outflow and on blood and lymph toxicity in acute myocardial infarct].

In experiments on rabbits it was found that acute myocardial infarction (AMI) was associated with a disorder of the drainage function the lymphatic system and a drastic increase of the lymph toxicity. The administration of propranolol (obsidan), amiodaron (cordaron), lidocaine (xycaine), trimecaine (mesocaine), nitroglycerin, panangin and heparin exerted the pronounced stimulating action on the lymph outflow rate. Strophanthin-K, corglycon and digo in possessed the moderate lymphogenic effect.

[Changes of electrolyte metabolism, acid-base equilibrium, and coagulation of blood and lymph in acute myocardial infarction].

Experiments were conducted on dogs to study disorders of the acid-base equilibrium (ABE), electrolyte metabolism, and the blood and lymph coagulation potential in different periods after the development of acute myocardial infarction (AMI). It was found that AMI modelling in dogs leads to marked changes of the values of the electrolyte metabolism, ABE, and coagulation of blood and lymph. Earlier and deeper disorders of many values occur in the lymph.

[Effect of obsidan on metabolic processes in the blood and lymph in acute myocardial infarction].

The effects of obsidan on lactate and glucose levels, the indices of ABB and electrolyte metabolism in blood and lymph at various times after development of the acute myocardial infarction were studied experimentally on dogs. It was stated that the earliest and most expressed changes of biochemical values were observed in the lymphatic system, thus pointing to its important role in the resorption and transport of the metabolic products from ischaemic myocardium. The use of obsidan during the development of acute myocardial infarction corrects substantially the disturbed metabolic processes in the blood and lymph.

[Endogenous intoxication of the body in acute myocardial infarct during lymph stimulation].

It was stated experimentally in dogs that the elevation of the lymph toxicity was more expressed than that of the blood in acute myocardial infarction. The shortening of the half-life period of paramecia evidenced the above mentioned fact. The injection of the lymphogogue preparations (obsidan, heparin, rheogluman) after coronary artery occlusion resulted in distinct rise of blood and lymph toxicity in early periods because of the "washing out" of toxic products from the ischemic myocardium, followed by normalization that had been more quicker than in controls.

[Stimulation of cardiac lymphatic drainage by obzidan, heparin and rheogluman in acute myocardial ischemia].

The state of the lymphatic heart perfusion has been studied experimentally on dogs with intact myocardium (control 1), with acute myocardial ischemia (AMI) model (control 2) and during injection of heparin, rheogluman and obsidan in AMI. It has been stated that AMI induces acute distress of the lymphatic heart perfusion system occurring at the first minutes after the onset of the focal myocardial ischemia. Heparin, rheogluman and obsidan demonstrated selective stimulating effect on the function of the lymphatic myocardial system.

[Drainage of the thoracic duct and changes in myocardial lymph drainage under conditions of electrothermocoagulation of the coronary artery].

It was demonstrated in dog experiments that the drainage function of the heart lymphatic system and coagulation of the central lymph are disturbed in acute myocardial infarction. Drainage of the thoracic duct with diversion of the flow of the toxic lymph fails to correct the diminished rate of lymph flow in the myocardium and does not prevent the increase of the hypercoagulation shift in the lymph. It is concluded that lymph stimulation and correction of the disorder of the lymph coagulation potential are necessary for effective pathogenetic treatment of myocardial infarction.

[Changes in lymph coagulation in experimental myocardial infarction after mammary-coronary artery anastomosis].

In the experiment on dogs, it was established that creation of the ++mammary-coronary anastomosis in myocardial infarction didn't eliminate the impairment of the lymph outflow in the myocardium, which resulted from the increase in the lymph coagulability.

[Lipid metabolism and lymph coagulability in the postresuscitation period].

The values of lipid metabolism and lymph coagulation in the restoration period after resuscitation were studied in experiments on rabbits. A clear correlation between the values was revealed. Increase of concentration of total lipids and of lipid fractions was accompanied by increase of the lymph coagulation potential, which led to disturbed tissue drainage of lymph and was one of the important causes of the development of postresuscitation complications.

[The blood and lymph electrolyte composition in the postresuscitation period].

The electrolyte composition (Na+, K+, Ca2+, Mg2+) of blood serum and lymph was studied in experiments on 17 mongrel dogs in the postresuscitation period after clinical death. The concentration of these electrolytes reduced in the postresuscitation period. Comparison of data obtained in study of blood and lymph showed the revealed changes to be of one trend.

[The structuro-functional state of the ischemic myocardium under the action of a terrilitin-nicotinic acid mixture in animal experiments].

Histochemical evidence of the activity and distribution of glycolysis redox enzymes, tissue respiration and terminal oxidation pattern (dehydrogenase of lactic, malic, succinic and isocitric acids, NAD-N- and NADPh-N-ase, cytochrome oxidase) as well as the levels of the major carbohydrates (glycogen, neutral aminopolysaccharides, glucose) were experimentally studied in the cardiomyocytes of myocardial necrotic, perinecrotic and intact areas in the control and in the experimental material under the administration of terrilitin-nicotinic acid mixture. It was stated that the use of aforementioned mixture contributed to the retention of enzymatic activity and optimal levels of energy formation in the cardiomyocytes of the marginal infarction zone and noticeably prevented the destructive involvement of the considered area as well as the impairment of functional activity of oscillating cardiomyocytes. Therefore, the application of the mixture improved the outcome prognosis in acute myocardial infarction.

[Approaches to the control of lymphogenic metastatic spread of tumors].

Lymphopoiesis stimulating drugs were injected into the blood of rabbits bearing Brown-Pearce transplantable tumor. It was found that treatment with mannitol targeted on osmoregulation mechanisms and terrilytin--on blood and lymph coagulation intensified the lymphogenic migration of tumor cells. When used in an experimental series involving endolymphic transplantation of tumor cells, the said drugs promoted tumor cell passage from lymph to blood, which resulted in an increased number of metastasis-bearing animals.