[Antidiabetogenic activity of maninyl].

Experiments were conducted on rabbits. A study was made of the effect of administration of maninyl (glybenclamide) into the stomach in a dose of 10 mg/kg of body weight for 7 days on the blood glucose level, insulin and zinc content in the pancreatic islands, and on the "dithizone" diabetes development. Maninyl administration was accompanied by a significant glycemia reduction.

[Effect of glibenclamide on insulin and zinc content in the islands of Langerhans].

The influence of glybenclamide on insulin and zinc content was studied in the pancreatic islets of rats, depending on the dose of the preparation and the time of study. The extent of hypoglycemia after the glybenclamide administration failed to correlate with the dose, whereas morphological changes in the gland were directly dependent on the dose of the preparation. The data obtained pointed to the pancreatotropic action of glybenclamide and confirmed the existence of zinc-insulin complex in beta-cells of the islets and its disintegration under the effect of this preparation.

[Role of the endocrine function of the islands of Langerhans in the mechanism of development of hypothalamic obesity].

Administration of alloxan to rats which developed hypothalamic adiposity damaged the pancreatic beta-cells and reduced the insulin secretion, thus arresting further weight gain despite some excess in food ingestion. A conclusion was drawn that in injury of the ventro-medial nuclei of the hypothalamus the most significant mechanism of obesity development was insulin hypersecretion induced by this action.

[Effect of fasting on the function of the islands of Langerhans in rats with hypothalamic obesity].

Experiments were conducted on albino rats with hypothalamic adiposity caused by electrolyte damage of the area of the ventro-medial nuclei of the hypothalamus; it was shown that the character of food regimen had a significant effect on the function of the islar apparatus of the pancreas and glucose tolerance. There was a marked increase in functional activity of the beta-cells of the pancreatic islands and disturbed carbohydrate tolerance in the animals kept on food rich in carbohydrates. Prolonged starvation in rats with hypothalamic adiposity decreased the morphometric indices of overstrain in the insulinogenic tissue, and normalized the glycemic curves.

[Alterations in the histostructure of the pancreas in experimental diabetes caused by quinoline derivatives].

Administration of chinoline derivatives, with a capacity to form stable complexes with metals (zinc?), was accompanied by a selective damage of the pancreatic islands with development of diabetes mellitus. Changes in the histostructure of the tissue caused by chinoline compounds of various chemical structure were unitypical. Their severity chiefly depended on the severity and duration of diabetes.