[Association of leptin and total immunoglobulin E in obese patients].

We measured by the immunoenzyme assay serum levels of total IgE and leptin in 17 men and 95 women with non-alcoholic fatty liver diseases (NAFLD) and in 57 men and 25 women with alcoholic liver disease (ALD) in comparison with 454 control men and 74 women without hepatic pathology. It was shown that the total serum IgE level in patients with ALD (229.5 +/- 31.

[Peculiarities of silicosis course in women engaged into metallurgy].

The study covers comparative analysis of silicosis course in males and females engaged into iron industry. Findings are more frequent combination of silicosis and chronic bronchitis in the females, without smoking habit. Some other differences in silicosis course and development were seen dependent on sex.

[Homocysteine and von Willebrand factor in chronic alcoholism].

The levels of homocysteine (HC) and von Willebrand factor (VWF) as cardiovascular risk factors were studied in patients with Stage II chronic alcoholism. Forty-one men with Stage II chronic alcoholism without clinical signs of somatic and infectious diseases were examined. Their median age was 37 (range 32-40) years; the alcoholization period was 12 (range 8-17) years.

[Hemostasis disorders in patients with occupational fluorosis are risk factors for IHD].

The studies covered hemostasis changes in workers with occupational fluorosis. The disorders diagnosed could be a risk factor for IHD in aluminium production workers

[Experience with the superselective third-generation beta-adrenoblocker nebivolol used to treat patients with prior myocardial infarction].

The effectiveness and safety of therapy with nebivolol and its effects on life quality (LQ) were studied in 71 patients with prior myocardial infarction (MI) with an ejection fraction of 40% or more. The follow-up lasted 1 year. The mean daily dose of the drug was 3.

[Effects of local vibration on development of ischemic heart disease in miners of South Kuzbas].

The incidence of ischemic heart disease (IHD) and risk factors of its genesis have been studied in 380 miners of a control group non-exposed to industrial vibration. Constitution type and a number of phenotypic signs have been determined for all examined workers with hemostatic indices defined in 60 miners before and after the performance of vibrational load test. High incidence of IHD, arterial hypertension and hyperholesterolemia have been detected in the miners working with vibration instruments and hemostatic disorders predisposing to ischemic heart disease have been revealed.

[Constitutional-morphologic features of coal miners exposed to vibration and suffering from coronary heart disease].

Occurrence of coronary heart disease and its risk factors are studied in individuals working with vibration instruments--in drift miners, miners of breakage face--and in 390 reference group miners who never faced occupational vibration. Findings are higher incidence of coronary heart disease, arterial hypertension and hypercholesterole mia in the miners working with vibration instruments. The main group miners suffering from coronary heart disease demonstrated more frequent hypersthenic constitutional type.

[Coronary heart disease, its risk factors and somatic types in coal miners having chronic dust-related diseases of lungs].

Studies covered incidence of coronary heart disease, its risk factors and features of constitutional types among Kouzbass coal miners suffering from anthracosilicosis and chronic dust bronchitis. Findings are reliably higher incidence of coronary heart disease among coal miners having lung diseases caused by dust. Coronary heart disease among the miners with anthracosilicosis is favored by arterial hypertension, overweight and hypersthenic constitutional type, that among those with dust bronchitis is favored only by overweight.

[Predicting the course of the post-infarction period by clinical signs and genetic markers].

The course of the postmyocardial infarction period was studied in 452 patients with previously determined genetic markers of 18 genetic polymorphic systems. Clinical and genetic factors related to an unfavourable course of the disease in male and female patients with myocardial infarction were identified. The data obtained enable development of the systems for long-term prognostication of the high risk of an unfavourable course of a 10-year postmyocardial infarction period.

[Hereditary polymorphism features in patients with silicosis associated with chronic bronchitis].

Chronic bronchitis frequently accompanies silicosis in metallurgy workers. Association of the two diseases significantly lowers life quality and disables the patients. Prophylactic measures for the diseases are elimination of the etiologic factors and detection of genetic markers for propensity and insusceptibility to silicosis and chronic bronchitis.

[Platelet hemostatic changes in patients with chronic alcoholism stage II in rest and exercise].

Platelet hemostasis was studied in 23 patients with chronic alcoholism (CA) stage II at rest and under muscular exercise. At rest, the patients had elevated spontaneous aggregation of platelets and more active start of adrenaline and ristomycin aggregation. Exercise stimulated spontaneous platelet aggregation, enhances adrenaline and ristomycin aggregation.

[The prediction of the probability of the development of myocardial infarct by genetic and phenotypic markers].

The study was made of marker distribution of 17 hereditary polymorphism systems in 493 patients with myocardial infarction (MI) and 422 healthy subjects. The prognostic system for determination of predisposition or resistance to MI development has been designed in accordance with marker occurrence in the patients and healthy subjects basing on Bayer's method. When the sum of the prognostic ratios of all the markers is +5 scores and more there is a high risk of MI, when this sum is -6 scores and less the resistance to its genesis is predicted.

[Role of genetic factors in the etiology of silicosis].

Examination of 15 systems of hereditary polymorphism including HLA system was conducted in 284 patients suffering from silicosis and 431 healthy subjects. The results provided genetic factors showing propensity to and resistance against silicosis. The data served as a base for silicosis risk groups formation among the staffers at occupational risk of silicosis, for occupational selection during placement to enterprises with silicosis danger.