[Idiopathic hypertrophic pachymeningitis].

The article presents a case of idiopathic hypertrophic pachymeningitis of a 61-year-old male patient with severe cephalgia and progressive neuropathy of the oculomotor nerves. The diagnosis was confirmed by MRI with gadolinium, which revealed thickening of the dura mater with accumulation of paramagnetic in the convexital parts of the frontal and temporal regions, as well as on the base of the skull and tentorium. During the use of pulse therapy with glucocorticosteroids (GCS) the symptoms regressed, but when the therapy was stopped, there was a relapse of ptosis and oculomotor abnormalities on the other side followed by a slower effect of GCS therapy.

Comparison of cell response to chromatin and DNA damage.

DNA-targeting drugs are widely used for anti-cancer treatment. Many of these drugs cause different types of DNA damage, i.e.

Human Immunodeficiency Virus Is Associated With Poor Overall Survival Among Patients With Head and Neck Cancer.

Background: Head and neck squamous cell cancer (HNSCC) occurs at higher rates among persons with HIV (PWH). This study compares the impact of sociodemographic and clinicopathologic characteristics on outcomes among PWH-HNSCC compared with HNSCC patients without HIV.

Methods: Patient data from HNSCC individuals were collected at a single academic hospital center between 2002 and 2018.

[Laser analyzer as an objective method for evaluating walking parameters in patients with post-stroke disorders].

Objective: To estimate the informativity, sensitivity and specificity of the method of assessing gait function in patients with ataxia and post-stroke hemiparesis using the LA-1 «Laser Analyzer of Kinematic Gait Parameters».

Materials And Methods: Main tempo-rhythm and spatial gait parameters were assessed in groups of healthy people of young (=30) and middle (=30) age. At the second stage, the gait parameters of healthy people were compared with those of patients with ataxia due to vertebrobasilar stroke (=30) and with post-stroke hemiparesis (=30).

[Ischemic stroke at a young age on the context of chronic myeloleukosis].

The article describes the clinical search for diagnosis and treatment of a patient who developed a severe ischemic stroke at a young age, when specifying the cause of which chronic myeloleucosis was identified. The unavailability of patient compliance and non-compliance with the recommended examination at the outpatient stage led to the development of severe complications. It would seem that the diagnosis of chronic myeloid leukemia, which does not represent excessive complexity, with the development of an acute condition in a young patient, such as an ischemic stroke, results in a complex diagnostic search, complicated by developing comorbidities due to general decompensation of the body.

[Stiff-person syndrome: a clinical observation].

Stiff-person syndrome (SPS) is a rare chronic neurological disease characterized by progressing muscle rigidity and painful muscle spasms. The signs of SPS are pain and stiffness in spinal, abdominal and cervical muscles, increased muscle tonus in extensor muscles of extremities, constant stiffness of paravertebral and abdominal muscles and muscle spasms. A clinical case of a SPS patient T.

[The detection of thrombocyte-bound IgG in patients with throbocytopenia].

The article presents the mode of detection of anti-thrombocyte auto-antibodies using flow cytometry technique. The values of IgG conjugated with thrombocytes are established in healthy persons. The rate of frequency of auto-antibodies to thrombocytes is analyzed in patients with primarily diagnosed immune thrombocytopenia, with relapse of disease and after therapy of immune thrombocytopenia.

[The analysis of changes bioelectrical activity of the muscles of the upper extremities in patients with traumatic deformation of the cervical spine].

The analysis of changes in bioelectrical activity of the muscles of the upper extremities was held with the help of electromyography in 37 patients with traumatic deformation of the cervical spine in order to identify its dependence on the nature of the initial damage, the amount of deformation and the terms of its existence. It was revealed that in the instrumental evaluation of patients with uncomplicated traumatic deformation of the cervical spine in 33.3 % of cases determined subclinical signs of neurological disorders in the form of changes in the bioelectric activity of the muscles of the upper extremities, most often in the DF and CF types.

[Evaluating psychophysiologic adaptation state in operators of Bilibino nuclear power station].

The study revealed that 60% operators of Bilibino nuclear power station suffer from psychosomatic diseases, 41.7% of them are assigned to occupational group of workers, and major part of the examinees with psychosomatic diseases (45.82%) are aged 41-50, high integral level ofpsychophysiologic adaptation is revealed in 5 examinees (12.

[The interpretation of immunophenotyping results during diagnostics of lymphatic proliferative disease using immunophenotyping count].

The article considers immune phenotyping heterogeneity of chronic lymphatic leukemia detected using basic diagnostic markers ofcell. The results of analysis of immune phenotypes of 108 patients with B-cell lymphatic proliferative diseases made it possible to establish that the atypical is related most rarely to indicators of expression of monotypic immunoglobulines and CD5 and most frequently to CD23, FMC7, CD22 and CS79b. During the present observation, the immune phenotyping count made up "3" or "2"points and the atypical alternative was registered among 10% of all examined patients with chronic lymphatic leukemia.

[Contemporary legislation and importance of psychophysiologic examination in system of medical support for workers engaged into production with radiation and nuclear danger].

In accordance with contemporary legislation, the article covers materials on specification and approbation of concept model for psychophysiologic examination in medical establishments during medical examination of workers engaged into production with raidation and nuclear danger. The authors defined methodology, examination methods and designed an order of psychophysiologic examination. The psychophysiologic examination and purpose-oriented rehabilitation appeared efficient.

[Evaluation of fludarabine-containing regimens versus immunochemotherapy for chronic lymphocytic leukemia].

Aim: to analyze the efficacy of RFC (rituximab, fludarabine, and cyclophosphan), FCM (fludarabine, cyclophosphan, and mitoxantrone), and FC (fludarabine and cyclophosphan) treatment programs in patients with chronic lymphocytic leukemia (CLL) in an open-labeled comparative controlled investigation.

Materials And Methods: The paper presents the authors' results of treatment in patients with progressive CLL in 2002 to 2007. The study included 229 patients, of them 78 patients received the RFC program, 72 had the FCM program, and 79 had the FC one.

[Epidemiologic and etiologic characteristic of enterovirus infections in Khabarovsk region].

Results of epidemiologic, virologic, and serologic studies of enterovirus infections in Khabarovsk region from 1975 to 2006 were analyzed. Patterns of epidemic process of these infections were established: periodic change of dominating type of pathogen in the population; onset of the large epidemic peaks of incidence during emergence of circulation of new for the given area serotypes of enteroviruses; possibility of realization of several routes of virus transmission. Role of water factor in the progress of the epidemic process was revealed.

[Transgenic fishes: modern state of the problem].

Transgenic fishes are the object for the specialists in different research fields. It seems very promising to cultivate the rapidly growing objects resistant to diseases and negative environmental factors as well as the indicators of pollutions, models for oncological investigations etc. Some methodical, piscicultural, medical, ecological and others aspects of investigations of transgenic fishes as well as the legislative basis of Ukraine on this problem are discussed in the article.

[BCG ostitis in children: the epidemiological parameters of some regions of the Russian Federation].

The incidence of BCG ostitis was studied by the data of questionnaires sent from 36 areas of the Russian Federation (RF). Particular emphasis is laid on 15 northwestern RF regions where an indepth study dealing with the 2000-2004 detection rates of postvaccination osseous complications was conducted. The mean incidence rate was 6.

Multiple enzymic activities of human milk lactoferrin.

Lactoferrin (LF) is a Fe3+-binding glycoprotein, first recognized in milk and then in other human epithelial secretions and barrier fluids. Many different functions have been attributed to LF, including protection from iron-induced lipid peroxidation, immunomodulation and cell growth regulation, DNA binding, and transcriptional activation. Its physiological role is still unclear, but it has been suggested to be responsible for primary defense against microbial and viral infection.

[Evaluation of reactogenicity and immunogenicity of Bubo-M, the Russian combined vaccine for immunization of adults against diphtheria, tetanus and viral hepatitis B].

Bubo-M, the first Russian associated vaccine, was found to have low reactogenicity and high immunogenic potency. The frequency of postvaccinal reactions in the group of persons immunized with Bubo-M (20%) appeared to be considerably lower than among persons who received the combined injection of adsorbed DT toxoid with reduced antigen content and vaccine against hepatitis B (47.7%).

[Vaccination of medical personnel against hepatitis B: epidemiological and socio-economic aspects].

Epidemiological and social aspects of the vaccinal prophylaxis of medical personnel against hepatitis B are discussed on the basis of the morbidity analysis in viral hepatitis, the results of dynamic screening for the presence of hepatitis B markers and the state of postvaccination immunity. The reactogenicity and immunogenicity of the vaccine "Euvax B", as well as the socio-economic effect of vaccinal prophylaxis, are evaluated.

[Importance of the eradication of the focus of infection and the synchronized correction of disturbed intestinal microflora in shigellosis patients].

The dynamic study of the characteristics of serum specific Shigella endotoxinemia was carried out in 60 patients with S.flexneri infection by EIA techniques. In addition, the level of Re-glycolipid in the blood of patients was determined in EIA with the use of Re-antibodies with the simultaneous study of the rectal microbiocenosis.

[The characteristics of the caseinolytic activity of the contents of the large intestine in dysbiotic states].

In the course of the study of the biochemical rapid method for the evaluation of microecological changes in the intestine by means of the test for the caseinolytic activity of fecal supernatants, the simultaneous presence of several enzymes in the samples under test was shown. Different degrees of the thermal inactivation of the active principle, linked with the expression of the positive caseinolytic sample, were established. The manifestations of caseinolytic activity, differing in their thermal stability, were found to have the proteolysis zone of equal size.

[The clinico-pathogenetic significance of the outer membrane proteins determined by the invasiveness plasmid in Flexner's shigellosis].

S. flexneri 2a outer membrane proteins of 38, 43, 62 and 78 kD, determined by the 140 mD invasiveness plasmid, serving as antigens and specific rabbit sera serving as antibodies were used for diagnosing S. flexneri infection in the enzyme immunoassay.

[Treatment of severe dysentery].

The paper presents analysis of clinical efficacy of etiotropic drugs in severe Flexner's dysentery chosen by sensitivity of the causing agent, schemes of antibacterial drugs of choice in the treatment of this disease, principles of detoxication therapy. Use of bacterial biological drugs in combined treatment of dysentery is validated.