Antimalarial activity of betulinic acid and derivatives in vitro against Plasmodium falciparum and in vivo in P. berghei-infected mice.

Malaria is one of the most important tropical diseases and mainly affects populations living in developing countries. Reduced sensitivity of Plasmodium sp. to formerly recommended antimalarial drugs places an increasing burden on malaria control programs as well as on national health systems in endemic countries.

Tetrahydroprotoberberine and aporphine alkaloids from rollinia leptopetala.

Tetrahydrojatrorrhizine, discretamine, anonaine and roemerine were isolated from the roots of Rollinia leptopetala R. E. Fries.