Long-term intake of Tamogi-take mushroom (Pleurotus cornucopiae) mitigates age-related cardiovascular dysfunction and extends healthy life expectancy.

Age-related declines in cardiac function and exercise tolerance interfere with healthy living and decrease healthy life expectancy in older individuals. Tamogi-take mushrooms (Pleurotus cornucopiae) are known to contain high levels of Ergothioneine (EGT), an antioxidant with potential health benefits. In this study, we assessed the possibility that long-term consumption of Tamogi-take mushrooms might attenuate age-related decline in cardiac and vascular endothelial function in mice.

Utility of 3D double-echo steady-state with water excitation (3D-DESS-WE) in diagnosing intraparotid facial nerve schwannoma: A case report.

Differentiating intraparotid facial nerve schwannoma from other parotid tumors, particularly pleomorphic adenoma, is clinically crucial due to significant differences in treatment approaches. We report a case of a male patient in his 70s presenting with a left parotid mass. Magnetic Resonance Imaging (MRI) revealed a mass within the left parotid gland exhibiting the characteristic ``target sign''.

In vitro to clinical efficacy: Neutralizing antibodies against severe acute respiratory syndrome coronavirus 2 strains.

Introduction: Neutralizing antibodies have been approved for coronavirus disease 2019 (COVID-19) treatment; however, no study has clarified the link among their neutralizing effect in vitro, the period of infectious virus shedding, and symptoms in the acute phase. Here, we aimed to assess the duration of virus shed and fever in patients with mild COVID-19 stratified by their characteristics and type of neutralizing antibody administered.

Methods: We evaluated the efficacy of neutralizing antibodies in terms of the duration of infectious virus excretion and fever in three groups: patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta strain treated with REGEN-CoV2 (REGN-CoV2 group) and patients infected with Omicron strain treated with S309 (S309 group) or untreated (untreated group).

Tetraarylphosphonium Cations with Excellent Alkaline-Resistant Performance for Anion-Exchange Membranes.

To realize the robust anion exchange membrane (AEM)-based water splitting modules and fuel cells, the design and synthesis of tetraarylphosphonium (TAP) cations are described as a new class of cationic building blocks that exhibit remarkable alkaline stability under harsh conditions. TAP cations with highly sterically demanding aromatic substituents were efficiently synthesized from triarylphosphine derivatives and highly reactive arynes, whose alkaline degradation proved to be suppressed dramatically by the sterically demanding substituents. In the case of bis(2,5-dimethylphenyl)bis(2,4,6-trimethylphenyl)phosphonium, for example, approximately 60% of the cation survived for 27 d under the forced conditions (i.

Dizziness and unstable gait in the older adults are associated with vestibular hypofunction, muscle dysfunction and sleep disturbance: impact on prevention of accidental falls.

Background: Dizziness and unstable gait with resultant falls are common symptoms among the older adults. Most of studies have focused on statistical analysis regarding single factor related to dizziness and unstable gait. On the other hand, there are very few comprehensive studies using a large number of patients except several review papers.

Additional benefits of belimumab in chronic phase of systemic lupus erythematosus and efficacy of tacrolimus combination therapy.

Systemic lupus erythematosus (SLE) is a typical autoimmune disease; although severe disease and refractoriness to existing therapies are still experienced, the number of cases resistant to remission induction has decreased with the establishment of various therapies. However, improving long-term prognosis remains a challenge due to the unavoidable prolonged use of non-selective glucocorticoids. To investigate the additional effect of belimumab in the chronic phase, we included 28 of 46 patients with SLE who were initiated on belimumab between January 2018 and October 2022 for glucocorticoid reduction.

Clinical Impact and Significant Technical Points of Transarterial Chemoembolization (TACE) Using the Smaller Drug-Eluting Bead M1 (DC Bead M1™) for Hepatocellular Carcinoma: A Case Series.

Background: This case series evaluated the clinical impact and significant technical points of transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) using the smaller drug-eluting bead (DEB) M1 (DC Bead M1; 70-150 µm).

Methods: We evaluated 12 patients and 14 HCC nodules treated with DEB-TACE using the DC Bead M1 (named DEM1-TACE). In addition to evaluating the early treatment efficacy for each treated node after DEM1-TACE, the study also used interventional radiology (IVR)- computed tomography (CT) to focus on the presence or absence of retention of the homogeneous contrast medium in target nodules after DEM1-TACE as a predictor of a good treatment response.

The role of anchoring information in judgments of learning.

This study examined informative and uninformative anchoring effects on judgments of learning (JOLs), focusing on two hypotheses: the optimistic/pessimistic and differential-scaling hypotheses. The optimistic/pessimistic hypothesis states that anchoring information changes subjective confidence in memory, whereas the differential-scaling hypothesis states that anchoring information elicits a scaling bias in the conversion process of subjective internal confidence into scale JOLs (i.e.

Bilateral vocal cord paralysis following ventriculoatrial shunt placement for hydrocephalus after subarachnoid hemorrhage: illustrative case.

Background: A ventriculoatrial (VA) shunt is an alternative to a ventriculoperitoneal (VP) shunt for managing hydrocephalus, especially when VP shunt insertion is not feasible. Despite its decline in use, the VA shunt remains vital for certain patients. This report highlights a rare complication of bilateral vocal cord paralysis following VA shunt insertion for hydrocephalus secondary to subarachnoid hemorrhage.

Spatial and time-resolved properties of emission enhancement in polar/semi-polar InGaN/GaN by surface plasmon resonance.

Light-emitting diodes (LEDs) are widely used as next-generation light sources because of their various advantages. However, their luminous efficiency is remarkably low at the green-emission wavelength. The luminous efficiencies of InGaN/GaN quantum wells (QWs) significantly decrease with increasing indium content in the green wavelength region, mainly owing to the quantum-confined Stark effect (QCSE).

Building vancomycin population pharmacokinetic model for Japanese low birth weight infants in comparing it with previously reported pediatric population pharmacokinetic models.

Background And Objectives: Vancomycin (VAN) is one of therapeutic agents for severe infections, and its efficacy and safety are subject to therapeutic drug monitoring. However, there is a lack of data regarding the administration of VAN to low birth weight (LBW) infants. This presents a challenge to ensure optimal dosing and maximize the benefits of VAN therapy in this specialized patients.

Chorioamnionitis and earlier gestational age are associated with neonatal hypercalcemia after maternal magnesium sulfate therapy: A case-control study.

Background: Magnesium sulfate (MgSO) is a tocolytic agent used to treat gestational hypertension and to prevent preterm labor. Neonatal hypocalcemia is a well-known side effect of maternal MgSO use. Cases of neonatal hypercalcemia after maternal MgSO have been reported.

Graft CD8 T cells for improving event-free survival after T cell-replete haploidentical stem cell transplantation in children with hematological malignancies.

T cell-replete haploidentical hematopoietic stem cell transplantation (TCR-haplo-HSCT) is a potentially curative therapy for pediatric intractable hematological malignancies due to its graft-versus-leukemia efficacy. This single-center cohort study examined the effects of graft composition (T cell type and dose) on pediatric TCR-haplo-HSCT outcomes in 32 children with relapsed/intractable hematological malignancies. Graft T cell composition was classified using flow cytometry.

Ligand-Dependent Intracluster Interactions in Electrochemical CO Reduction Using Cu Nanoclusters.

The electrochemical CO reduction reaction (CORR) has been extensively studied because it can be leveraged to directly convert CO into valuable hydrocarbons. Among the various catalysts, copper nanoclusters (Cu NCs) exhibit high selectivity and efficiency for producing CORR products owing to their unique geometric/electronic structures. However, the influence of protective ligands on the CORR performance of Cu NCs remains unclear.

Diverse NKT cells regulate early inflammation and neurological outcomes after cardiac arrest and resuscitation.

Neurological injury drives most deaths and morbidity among patients hospitalized for out-of-hospital cardiac arrest (OHCA). Despite its clinical importance, there are no effective pharmacological therapies targeting post-cardiac arrest (CA) neurological injury. Here, we analyzed circulating immune cells from a large cohort of patients with OHCA, finding that lymphopenia independently associated with poor neurological outcomes.

A Mother and Daughter with Tinea Corporis Caused by Microsporum canis Apparently Transmitted from a Domestic Cat.

The patient was a girl (case 1) and her mother (case 2). The family had purchased a domestic cat five months previously. Three months later, both patients developed eruptions.

Inhibitory effects of the selective μ-opioid receptor antagonist UD-030 on methamphetamine-induced conditioned place preference.

Although methamphetamine (METH) and other addictive substance use disorders are a major social problem worldwide, appropriate pharmacotherapies have not yet been discovered. Subtype-nonselective opioid receptor antagonists, such as naltrexone (NTX), have been reported to suppress METH addiction, but unclear are the opioid receptor subtypes that are involved in this beneficial effect. To clarify the role of μ-opioid receptors (MOPs), we examined effects of the novel nonpeptidic MOP-selective antagonist UD-030 on the acquisition and expression of METH-induced conditioned place preference (CPP) using behavioral tests in C57BL/6J mice.

An Evaluation of the Most Convenient and Effective Procedure for Reducing the Loading Time of Epirubicin Into the Drug-Eluting Bead M1 (DC Bead M1™).

Background and objective Drug-eluting beads (DEB) have been highly useful in the current treatment strategies for multiple and large hepatocellular carcinomas (HCC) with or without systemic therapy. Recently, smaller beads have become available in Japan. In this study, we aimed to evaluate the most convenient and effective way to reduce the loading time of epirubicin into the drug-eluting beads M1 (DC Bead M1; 70-150 µm).

Clinical characteristics and results after conservative treatment or interfascicular neurolysis of 100 limbs with spontaneous anterior interosseous nerve palsy: A prospective Japanese multicenter study.

Background: Spontaneous anterior interosseous nerve (AIN) palsy is characterized by the sudden onset of upper limb pain followed by weakness of muscles mainly innervated by the AIN. Although this palsy is conventionally treated conservatively, interfascicular neurolysis to release hourglass-like fascicular constrictions has been recommended. The present study aimed to establish the clinical characteristics and treatment strategy for this condition.

The added value of using convective-permitting regional climate model simulations to represent cloud band events over South America.

Climate science has long explored whether higher resolution regional climate models (RCMs) provide improved simulation of regional climates over global climate models (GCMs). The advent of convective-permitting RCMs (CPRCMs), where sufficiently fine-scale grids allow explicitly resolving rather than parametrising convection, has created a clear distinction between RCM and GCM formulations. This study investigates the simulation of tropical-extratropical (TE) cloud bands in a suite of pan-South America convective-permitting Met Office Unified Model (UM) and Weather Research and Forecasting (WRF) climate simulations.