Development of a 3D-printed phantom for total skin electron therapy dose assessment.

Purpose: Total skin electron therapy (TSET) is a complex radiotherapy technique, posing challenges in commissioning and quality assurance (QA), especially due to significant variability in patient body shapes. Previous studies have correlated dose with factors such as obesity index, height, and gender. However, current treatment planning systems cannot simulate TSET plans, necessitating heavy reliance on QA methods using standardized anthropomorphic phantoms and in-vivo dosimetry.

Circulation of Non- Species in Niger: Implications for Malaria Diagnosis.

Background: Niger's National Malaria Control Programme and its partners use histidine-rich protein 2-based RDTs, which are specific to diagnosis. This study aimed to screen for the circulation of non- species in Zinder, a region of Niger, West Africa.

Methods: A cross-sectional study was carried out from July to December 2022 at the district hospital of the Zinder region of Niger.

ProSol-multi: Protein solubility prediction via amino acids multi-level correlation and discriminative distribution.

Protein solubility prediction is useful for the careful selection of highly effective candidate proteins for drug development. In recombinant proteins synthesis, solubility prediction is valuable for optimizing key protein characteristics, including stability, functionality, and ease of purification. It contains valuable information about potential biomarkers or therapeutic targets and helps in early forecasting of neurodegenerative diseases, cancer, and cardiovascular disorders.

The Impact of Diabetes Education by Clinical Pharmacist on Quality of Life and Treatment Satisfaction of Sudanese Individuals With Type II Diabetes Mellitus: Randomized, Double-Blind, Controlled Trial.

Background: Patients' satisfaction with their treatment directly impacts the control of their diabetes. Quality of life is crucial for patients with diabetes mellitus to maintain long-term health and minimize complications. The current study aimed to evaluate the impact of diabetes education on quality of life (QoL) and treatment satisfaction of patients with type 2 diabetes mellitus.

Neurofibromatosis type 1 (NF1) presenting with dichotomous pubertal presentation: A case series.

Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder that is caused by a mutation in the NF1 gene, which is located on chromosome 17q11.2, which encodes for a protein known as "Neurofibromin", which acts as an inhibitor of oncogene RAS. This gene mutation causes tumours to grow on nerves which results in other systemic abnormalities such as skin changes, bone and eye abnormalities, hormonal imbalances, and diversity in achievement of puberty with neurologic complications.

Computer-aided discovery of novel SmDHODH inhibitors for schistosomiasis therapy: Ligand-based drug design, molecular docking, molecular dynamic simulations, drug-likeness, and ADMET studies.

Schistosomiasis, also known as bilharzia or snail fever, is a tropical parasitic disease resulting from flatworms of the Schistosoma genus. This often overlooked disease has significant impacts in affected regions, causing enduring morbidity, hindering child development, reducing productivity, and creating economic burdens. Praziquantel (PZQ) is currently the only treatment option for schistosomiasis.

Leadership at the helm: Essential skills and knowledge for effective management in Islamic Economics and Finance schools.

A skilled principal is an invaluable asset in the evolving landscape of higher education institutions, where challenges continually arise and the global economy demands adaptability. This study explored the essential skills and knowledge necessary for principal roles in Islamic Economics and Finance (IEF) schools. A qualitative multiple-case study approach was employed, and semi-structured interviews were conducted with 34 academics from four IEF schools at public universities in Saudi Arabia and Malaysia.

Curriculum, competency development, and assessment methods of MSc and PhD pharmacy programs: a scoping review.

Background/objectives: We aim to systematically review and evaluate the current landscape of postgraduate pharmacy education to a) identify current evidence, best practices, challenges, recommendations, and solutions; and b) develop a framework to optimize postgraduate pharmacy programs.

Methods: A scoping review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR). Electronic databases, including PubMed, Scopus, EMBASE, ProQuest, Web of Science, and Google Scholar were utilized.

Molecular detection of Anaplasma bovis, Candidatus Anaplasma boleense and Rickettsia spp. in ticks infesting small ruminants.

Anaplasma spp. and Rickettsia spp. are intracellular vector-borne pathogens and harbored by a wide range of ticks and vertebrate hosts.

Crack densification in drying colloidal suspensions.

As sessile drops of aqueous colloidal suspensions dry, a close-packed particle deposit forms that grows from the edge of the drop toward the center. To compensate for evaporation over the solid's surface, water flows radially through the deposit, generating a negative pore pressure in the deposit associated with tensile drying stresses that induce the formation of cracks. As these stresses increase during drying, existing cracks propagate and additional cracks form, until the crack density eventually saturates.

Exploring Holy Basil's Bioactive Compounds for T2DM Treatment: Docking and Molecular Dynamics Simulations with Human Omentin-1.

Type 2 Diabetes Mellitus (T2DM) presents a substantial health concern on a global scale, driving the search for innovative therapeutic strategies. Phytochemicals from medicinal plants, particularly Ocimum tenuiflorum (Holy Basil), have garnered attention for their potential in T2DM management. The increased focus on plant-based treatments stems from their perceived safety profile, lower risk of adverse effects, and the diverse range of bioactive molecules they offer, which can target multiple pathways involved in T2DM.

Computer vision and statistical insights into cycling near miss dynamics.

Across the globe, many transport bodies are advocating for increased cycling due to its health and environmental benefits. Yet, the real and perceived dangers of urban cycling remain obstacles. While serious injuries and fatalities in cycling are infrequent, "near misses"-events where a person on a bike is forced to avoid a potential crash or is unsettled by a close vehicle-are more prevalent.

Development of cellulose acetate poly acrylonitrile (CAPA)-SiC/epoxy coating to mitigate corrosion of copper in chloride containing solutions.

A new conducting polymer of the cellulose acetate poly acrylonitrile (CAPA)-SiC composite was produced using an in situ oxidative polymerization technique in an aqueous medium. SiC was synthesized from Cinachyrella sp. as a source of carbon and silicon at 1200 °C under an argon atmosphere via a catalytic reduction process.

Nasopharyngeal and temporal bone abscess following necrotizing otitis externa: a case report.

Necrotizing otitis externa (NOE) is a severe infection primarily affecting the external auditory canal, seen mainly in immunocompromised individuals as patients with diabetes mellitus (DM). This case report highlights unusual complications of NOE: temporal bone and nasopharyngeal abscesses. These complications underscore the severity of NOE, particularly when caused by rare pathogens such as Klebsiella species.

Development and Evaluation of Solidified Supersaturated SNEDDS Loaded with Triple Combination Therapy for Metabolic Syndrome.

The present study aimed to develop and optimize solidified supersaturated self-nanoemulsifying drug delivery systems (SNEDDS) for the combined administration of antihypertensive, antihyperglycemic, and antihyperlipidemic drugs to enhance their solubility and dissolution during the treatment of metabolic syndrome. Various SNEDDS formulations were prepared and subjected to pharmaceutical assessment. The solubility of candesartan (CC), glibenclamide (GB), and rosuvastatin (RC) in SNEDDS and supersaturated SNEDDS formulations was evaluated.

Programmed death-ligand 1 expression in patients with primary or secondary myelofibrosis.

Background: It has been described in mice models that myeloproliferative neoplasm (MPN) with JAK2-V617F mutation has an increased expression of programmed death-ligand 1 (PD-L1) in megakaryocytes leading to cancer immune evasion by inhibiting the T-lymphocytes.

Aims: To quantify and compare the PD-L1 expression on bone marrow (BM) of patients with MPN JAK2 positive, negative, and normal controls.

Methods: We collected BM of patients with MPN JAK2 positive, negative and normal controls from 1990 to 2019.

Crystal structure of Kunitz-type trypsin inhibitor: Entomotoxic effect of native and encapsulated protein targeting gut trypsin of Herbst.

Trypsin inhibitors are known to act against insect pests by inhibiting proteases of the digestive tract. In this study, we report structural and functional characterization of ∼ 19 kDa Kunitz-type trypsin inhibitor (ApKTI) protein with potential bio-insecticidal applications. Crystal structure of ApKTI protein has been refined to 1.