Publications by authors named "I. Iu. Mironova"

Treatment of long and diffuse lesions of coronary arteries remains one of most complicated sections of endovascular treatment. From 2003 to 2005 treatment with the use of stents with drug coating was conducted in 198 patients with long and diffuse coronary artery lesions. This made up 26% of total number of patients subjected to percutaneous coronary intervention during this time.

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Aim: To assess antianginal and antiischemic effects of trimetazidine and its action on myocardial perfusion in patients with ischemic heart disease and stable angina.

Material: Open trimetazidine was given for 3 months to 53 nitroglycerine and beta-blocker treated men aged 47-69 (mean age 60.2+/-0.

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We compared early and long-term follow-up results of balloon angioplasty and stenting of chronic coronary occlusions. The initial success rate was 75% (82 of 109 patients). Proportion of patients free of angina was 57 and 69% after successful balloon angioplasty and stenting, respectively.

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An association of arterial hypertension (AH) and late angiographic outcomes of endovascular interventions was studied in coronary heart disease. Forty two patients with or without AH underwent repeated coronary angiography within 2 months after the procedure. The total number of restenoses was found to be significantly greater in patients with AH than in those without it.

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The aim of this study was to assess clinical parameters in patients with coronary heart disease (CHD) in the late period after balloon coronary angioplasty (BCA) and intracoronary stenting (ICS). The study included 104 patients who underwent repeated coronary angiography (CA) 2-10 months after successful coronary angioplasty. Clinical parameters were analyzed in 2 groups comparable at the moment of its performance in terms of major clinical characteristics.

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The new calcium antagonist nicardipine was studied for its potency in 73 patients with coronary heart disease concurrent with angina pectoris, including 16 with vasospastic angina. Nicardipine given in a mean daily dose of 70.1 +/- 12.

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The diagnostic importance of transesophageal pacing of the atria (TPA) in revealing coronary heart disease was determined by means of comparing the pacing data with the clinical picture of the disease and coronarography readings in 231 patients. It is shown that the sensitivity of TPA in CHD diagnosis is equal to 80%, specificity to 70%, the predicting value of the positive result amounts to 86%, of the negative result to 59%. The greatest diagnostic importance belongs to the positive result of TRA in patients with typical angina pectoris and to the negative result in patients with cardialgia.

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Antianginal efficiency of dilzem, as compared to placebo, was assessed in 53 patients with angina of effort, functional class II-IV. Repeated bicycle ergometry and 24-hour ECG monitoring were used as objective methods for the assessment of treatment efficiency. Antianginal effect of dilzem (180-300 mg/daily) was compared to that of corinfar (30-60 mg/daily) in 16 patients by a simple blind cross procedure, using placebo.

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The efficiency of 20 mg corinfar, administered sublingually, was assessed by means of esophageal left-atrial electrostimulation (EES) in 49 coronary patients with angina of functional classes 1 through 4. The antiischemic effect of corinfar was evaluated within 30 min after the administration in 27 patients and within 1 hour after the administration in 22 patients. To assess the reproducibility of the results, repeated EES was performed in 11 patients, treated with placebo this time.

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Anti-ischemic effect of sorbide nitrate was assessed by means of esophageal left-atrial electric stimulation in 26 coronary patients. This method is shown to be useful for objective assessment of the efficiency of antianginal drugs by acute tests in coronary patients. Repeated stimulation in the presence of sorbide nitrate treatment showed smaller ischemic ECG changes.

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