Climate Change-Associated Environmental Factors and Pollutants: Impact on Allergic Diseases, Epidemiology, Severity, and Health Care Burden.

Background: Allergic diseases affect up to 40% of adults worldwide, a percentage that is increasing with environmental changes related to global warming.

Methods: A systematic review of the literature was performed to identify and evaluate current evidence of the effect of climate change-related environmental factors on the prevalence, incidence, and severity of allergic diseases in terms of the impact on patients with allergy. PECO criteria for 2 research questions were established and guided the literature searches of the PubMed and Cochrane databases (January 1, 2016 to December 31, 2021).

Pathophysiology of referred pain in dentistry: a case report.

This article presents the clinical case of a 42-year-old woman with chronic pain in her left temporomandibular joint (TMJ) and limited mouth opening. The patient also reported anxiety and difficulty sleeping. Cone beam computed tomography revealed impacted maxillary third molars and hypertrophy of the nasal turbinates.

"Someday, I'll be an ancestor:" Understanding indigenous intergenerational connectedness through qualitative research to inform measure development.

Intergenerational connectedness broadly encompasses relations among humans, lands, and all living and spiritual beings, and functions as an important part of Indigenous well-being. Many public health campaigns and interventions aim to promote connectedness to support holistic wellness and reduce health inequities. Currently, however, there are no measurement tools to assess intergenerational connectedness to support culturally grounded research and program evaluation.

Severity of Achilles Tendinopathy on Preoperative MRI and Short-term Functional Outcomes After Minimally Invasive Zadek Osteotomy.

Background: Limited literature is available to guide surgeons on which patients with insertional Achilles tendinopathy (IAT) may be the best candidates for minimally invasive dorsal closing wedge calcaneal Zadek osteotomy (MIS ZO). We hypothesized that the severity of IAT on preoperative magnetic resonance image (MRI) may correlate with post-operative functional outcomes and help guide patient selection for treatment with MIS ZO.

Methods: Patients who underwent MIS ZO for IAT ± Haglund deformity were identified and retrospectively analyzed.

Evaluating the Effect of Epigallocatechin Gallate (EGCG) in Reducing Folate Levels in Reproductive Aged Women by MTHFR and DHFR Genotype in Combination With Letrozole or Clomiphene.

Previous epidemiological studies have suggested that green tea catechins, including Epigallocatechin-3-gallate (EGCG), the most abundant polyphenol in green tea, may be associated with reduced serum folate levels. This is of particular interest as women of childbearing age may be consuming EGCG from tea, dietary supplements, or involved in active clinical trials studying EGCG or green tea extract. EGCG was reported to shrink uterine fibroids in preclinical and clinical studies.

Assessment of Food Effect and pH-Dependent Drug-Drug Interactions of Fruquintinib in Healthy Subjects.

This two-sequence, three-period study (NCT04645940) was designed to evaluate the effect of food and concomitant rabeprazole, a proton pump inhibitor, on the pharmacokinetics (PK) and safety of fruquintinib and its metabolite M11 after a single oral dose of fruquintinib 5 mg in healthy subjects. In the food effect treatment periods, 14 subjects were randomized in a 1:1 ratio utilizing a two-sequence (fed/fasted vs. fasted/fed), two-period, cross-over design.

Determination and Comparison of Fat and Fibre Contents in Gluten-Free and Gluten-Containing Flours and Breads: Nutritional Implications.

The absence of gluten is a technological challenge that requires the addition of components to replace the unique viscoelastic properties of gluten, thus altering the nutritional composition of gluten-free (GF) breads. Moreover, GF flours may have different compositions as compared to gluten-containing (GC) counterparts because of a different origin. This may impact the nutritional quality of GF diets.

Exploring the In Vitro Photoprotective Effect of a Combination of Natural Extracts: First Steps in Developing New Technologies for Photoprotection Strategies.

There is a need for new technologies in photoprotection. The negative effects of solar exposure on the skin have been amply demonstrated and there is an urgency for the development of alternative photoprotective approaches. In this respect, natural extracts represent the most interesting and promising source.

Advanced Doppler Ultrasound Insights: A Multicenter Prospective Study on Healthy Skin.

There have been multiple studies on the use of Doppler ultrasound to define skin inflammation, but the visible vessels of healthy skin have yet to be described. This study aimed to evaluate the visible vessels of healthy skin using Doppler ultrasound. Prospective multicenter study using Doppler ultrasound to analyze healthy skin.

Diversity equity and inclusions in an academic surgery department: Exploring the present and building a future.

Introduction: The University of Washington Department of Surgery (DoS) Diversity Council created a survey to understand our socio-demographics, identify gaps regarding Diversity, Equity and Inclusion (DEI) initiatives, and support efforts prioritizing DEI.

Methods: An anonymous, voluntary online survey was administered over 5 weeks to DoS members. Quantitative and qualitative analysis were performed using SurveyMonkey and Dedoose, respectively.

Eficacia y seguridad del ácido hipocloroso pH 5,5 en el manejo de heridas complejas en usuarios pediátricos.

Serie de casos que sugieren los beneficios de la implementación de una solución limpiadora no citotóxica de pH ácido en el tratamiento de heridas complejas en usuarios pediátricos en dos centros de salud de Santiago, Chile. Se propone como tratamiento adicional al manejo etiológico el uso de una solución limpiadora compuesta de ácido hipocloroso (HOCl) en una concentración de 330 ppm y pH 5,5 (Vashe® Wound Solution, Urgo Medical, Texas, Estados Unidos) la cual ha demostrado ser segura y efectiva en el manejo de heridas en usuarios pediátricos. Se evidencian beneficios significativos en términos de cicatrización acelerada y reducción del dolor en los casos tratados.

A global cross-sectional survey on neonatal analgosedation: unveiling global trends and challenges through latent class analysis.

Purpose: This study aims to analyze global prescribing patterns for analgosedation in neonates during four critical care scenarios. The research explores existing patterns, their association with geographic and sociodemographic index (SDI), and adherence to evidence-based practices.

Methods: Data from a 2024 global survey of 924 responses to 28 questions were analyzed, focusing on four items for their high variability: premedication in intubation (Q17), sedation in preterm (Q19) and full-term newborns (Q23), and perinatal asphyxia (Q26).

Immunity and neuroinflammation in early stages of life and epilepsy.

The immune system is crucial for the correct brain development, and recent findings also point toward central control of immune response. As the immune system is not fully developed at birth, the early years become an important window for infections and for the development of epilepsy. Both central and even peripheral inflammation may impact brain function, promoting opening of the blood-brain/blood and cerebrospinal barriers and allowing entry of immune cells and cytokines, which in turn may affect neuron function and connections.

Multiscale Mechanical Characterization of Mineral-Reinforced Wood Cell Walls.

Studying the multiscale mechanics of bio-based composites offers unique perspectives on underlying structure-property relations. Cellular materials, such as wood, are highly organized, hierarchical assemblies of load-bearing structural elements that respond to mechanical stimuli at the microscopic, mesoscopic and macroscopic scale. In this study, we modified oak wood with nanocrystalline ferrihydrite, a widespread ferric oxyhydroxide mineral, and characterized the resulting mechanical properties of the composite at various levels of organization.

Systematic study of hybrid triplex topology and stability suggests a general triplex-mediated regulatory mechanism.

By combining in silico, biophysical, and in vitro experiments, we decipher the topology, physical, and potential biological properties of hybrid-parallel nucleic acids triplexes, an elusive structure at the basis of life. We found that hybrid triplex topology follows a stability order: r(Py)-d(Pu)·r(Py) > r(Py)-d(Pu)·d(Py) > d(Py)-d(Pu)·d(Py) > d(Py)-d(Pu)·r(Py). The r(Py)-d(Pu)·d(Py) triplex is expected to be preferred in the cell as it avoids the need to open the duplex reducing the torsional stress required for triplex formation in the r(Py)-d(Pu)·r(Py) topology.

Fluorescent PyrAte-()-citalopram conjugates enable imaging of the serotonin transporter in living tissue.

Fluorescent labeling techniques have enabled the visualization of various biomolecules, cellular structures, and their associated physiological processes. At the same time, there remains a demand for developing novel fluorescent compounds possessing unique chemical properties for biological imaging. A recently developed class of fluorophores, termed , displays optimal brightness and large Stokes shifts that are ideal for fluorescence microscopy.

Ironing out the conflicts: iron supplementation reduces negatives bacterial interactions in the rhizosphere of an Atacama-endemic perennial grass.

Background: In plants, root exudates selectively influence the growth of bacteria that colonize the rhizosphere. Bacterial communities associated with root systems are involved in macro and micronutrients cycling and organic matter transformation. In particular, iron is an essential micronutrient required for the proper functioning of iron-containing enzymes in processes such as photosynthesis, respiration, biomolecule synthesis, redox homeostasis, and cell growth in plants.

Drivers of Job Loss Among Chinese Breast Cancer Survivors: A Qualitative Analysis.

Purpose: This study aimed to understand the reasons for the high risk of job loss previously identified among foreign-born Chinese breast cancer survivors in the United States Qualitative interviews were conducted to explore challenges leading to job loss during/after treatment and to help identify potential interventions to promote job retention and re-employment.

Patients And Methods: The research team conducted semi-structured interviews with foreign-born Chinese breast cancer survivors in New York City. A total of 12 participants, previously enrolled in the Breast Cancer and the Workforce study, were interviewed between February and November 2018.

Prospective assessment of learning curve and impact of intensive versus progressive training in colonoscopy competence among French residents.

Backgrounds: There are no existing data in the literature on the learning curve of French interns in colonoscopy or on the comparison between different frequencies of colonoscopy training modalities. We aimed to assess the number of procedures required for French residents in hepatogastroenterology to achieve competency in colonoscopy.

Methods: The primary outcome was achieving greater than 90% cecal intubation rate (CIR90) competency using the Learning Curve-Cumulative Summation (LC-CUSUM) method.

Update on preclinical models of cancer therapy-related cardiac dysfunction: Challenges and perspectives. A scientific statement of the Heart Failure Association (HFA) of the ESC, the ESC Council of Cardio-Oncology, and the ESC Working Group on Cellular Biology of the Heart.

New anticancer therapies with potential cardiovascular side effects are continuously being introduced into clinical practice, with new and often unexpected toxicities becoming apparent only after clinical introduction. These unknown toxicities should be identified and understood beforehand to better prepare patients and physicians, enabling the implementation of effective treatments. Therefore, there is a crucial need for appropriate preclinical models to understand the biological basis of their cardiotoxicity.

Risk Factors and Thresholds for Minimal Clinically Important Difference in Worsening after Unicompartmental Knee Arthroplasty.

Background: The rising demand for unicompartmental knee arthroplasty (UKA) in the United States has led to high one-year patient satisfaction rates. However, some patients experience substantial declines in patient-reported outcome measures (PROMs) post-operatively, which we refer to as "Minimal Clinically Importance Difference for Worsening " (MCID-W). We sought to define MCID-W values for specific PROMs and identify risk factors associated with PROMIS Physical Function Short Form 10a (PROMIS PF-10a) declines after UKA.

INFECTIOUS ENTEROCOLITIS IN HEMATOPOIETIC CELL TRANSPLANT WITH POST-TRANSPLANT CYCLOPHOSPHAMIDE.

Background: Despite the high incidence of diarrhea in hematopoietic cell transplant (HCT) recipients, data on infectious enterocolitis with post-transplant cyclophosphamide (PTCy) for graft-versus-host disease (GVHD) prophylaxis remain limited.

Objectives: Evaluate the characteristics, incidence, risk factors, and impact on outcomes of infectious enterocolitis in patients with hematologic malignancies undergoing HCT from matched sibling, matched unrelated, and haploidentical donors using PTCy as GVHD prophylaxis.

Study Design: Retrospective analysis of infectious enterocolitis episodes in 399 patients undergoing HCT at a single institution.

Genetic subtyping by Whole Exome Sequencing across Diffuse Large B Cell Lymphoma and Plasmablastic Lymphoma.

Diffuse Large B-Cell Lymphoma (DLBCL) is a heterogeneous disease characterized by a limited number of molecularly defined subtypes. Recently, genomic-based algorithms have been proposed for the classification of this disease. The whole exome sequencing was conducted on 108 diagnostic samples of diffuse large B-cell lymphoma (DLBCL).