Publications by authors named "I-Seul Joe"
Functional restoration of replicative senescent mesenchymal stem cells by the brown alga .
Anim Cells Syst (Seoul)
March 2017
Article Synopsis
- The brown alga Mi-Yoek, commonly eaten in East Asia, has been shown in studies to help with various health issues like inflammation and fat metabolism.
- Researchers explored how ethanol extracts from this alga (UP-Ex) impact human bone marrow mesenchymal stem cells (hBM-MSCs) and found that UP-Ex helps protect these cells from oxidative damage.
- Treatment with UP-Ex not only reduced oxidative stress but also improved the ability of aging hBM-MSCs to differentiate into other cell types, indicating it may enhance stem cell therapy effectiveness.
Cyclin Y (CCNY), which is a cyclin protein known to play a role in cell division, is unexpectedly and thus interestingly expressed in non-proliferating neuronal cells. There have been only a few studies reporting the neuronal functions of CCNY in synapse remodeling and hippocampal long-term potentiation. Therefore, we here provide global and comprehensive information on the putative functions of CCNY in biological and functional pathways in neuronal systems.
View Article and Find Full Text PDFIncreased intracellular cyclic adenosine monophosphate (cAMP) can promote axonal elongation and facilitate neuronal repair, while decreased cAMP is associated with losses in neuronal regenerative capacity. Rolipram, which upregulates intracellular cAMP by blocking phosphodiesterase-4 (PDE4) enzyme activity, can mitigate diverse neurological disorders. In this study, we investigated whether rolipram induces neuronal differentiation of human bone marrow-mesenchymal stem cells (hBM-MSCs).
View Article and Find Full Text PDFArticle Synopsis
- Resveratrol (RSV) is a natural compound that protects against stress and enhances neuroprotection through activation of sirtuin1.
- In this study, RSV significantly increased markers for neuroprogenitor cells in human bone marrow-mesenchymal stem cells (hBM-MSCs), indicating promoted neuronal differentiation.
- RSV-treated MSCs exhibited neuron-like morphology and higher expression of neuronal markers, effects that were inhibited by a sirtuin1 blocker, confirming RSV's role in encouraging neuronal differentiation.