Publications by authors named "I-Min Lee"
Background: Venous stasis, which can occur with prolonged sedentary behavior (SB), is associated with venous thromboembolism (VTE) risk, but VTE risk associated with accelerometer-measured SB has not been quantified.
Objectives: To evaluate accelerometer-based measures of SB in relation to incident VTE.
Methods: We included 5,591 participants, aged 63-99 years, of the Women's Health Initiative Objective Physical Activity and Cardiovascular Health cohort study without prior VTE.
: While previous study results have suggested an elevated risk of type 2 diabetes with potato consumption, limited and inconsistent results are available on the association of potato consumption with the risk of cardiovascular disease (CVD) and hypertension (HTN). We assessed the associations of (i) total potato consumption with the risk of CVD and HTN as the primary aim and (ii) fried potatoes and combined baked, boiled, and mashed potatoes with the risk of CVD and HTN as the secondary aim. : We conducted a meta-analysis using data from seven cohorts for CVD ( = 110,063) and five cohorts for HTN ( = 67,146).
View Article and Find Full Text PDFBackground: Previous estimates of the number of cancers attributable to physical inactivity in the United States have typically focused on only three malignancies (colon, endometrial, and postmenopausal breast cancer). Contemporary epidemiologic evidence suggests that physical inactivity could contribute to up to 15 types of cancer, and a dose-response effect has been demonstrated for 13 of these. This study estimated the number of cancers diagnosed in the United States in 2015 due to physical inactivity for these 13 sites.
View Article and Find Full Text PDFBackground: It remains unclear whether supplementation with vitamin D reduces risk of acute exacerbations of chronic obstructive lung disease (COPD) or asthma, major contributors to the world-wide burden of disease.
Objectives: To compare effects of vitamin D with placebo supplementation for the prespecified primary endpoints 1) acute exacerbations of COPD and 2) decline in pulmonary function measures of airflow obstruction. Prespecified secondary endpoints included asthma exacerbations and control.
Objective: To compare physical activity (PA) over midlife between (1) former collegiate athletes and non-athletes and (2) among athletes in different sports.
Methods: The Harvard Alumni Health Study (HAHS) is a prospective cohort study of male undergraduates who completed serial questionnaires regarding PA and health status between 1962 and 1993. PA was categorised by intensity (<3 METs, light; 3 to <6 METs, moderate; ≥6 METs, vigorous), and energy expenditure (kilocalories (kcal)/week) was estimated at each intensity and in total.
Background: There are no studies examining the prospective joint association of device-based measures of sedentary time and physical activity (PA) with cancer mortality. We examined the joint associations of sedentary time and intensity-specific PA with cancer mortality in 72,458 adults from UK Biobank.
Methods: Participants wore an Axivity AX3 accelerometer on their dominant wrist for at least 3 days (with at least 1 weekend day).
Background: Blood pressure (BP)-lowering effects of structured exercise are well-established. Effects of 24-hour movement behaviors captured in free-living settings have received less attention. This cross-sectional study investigated associations between a 24-hour behavior composition comprising 6 parts (sleeping, sedentary behavior, standing, slow walking, fast walking, and combined exercise-like activity [eg, running and cycling]) and systolic BP (SBP) and diastolic BP (DBP).
View Article and Find Full Text PDFBackground: Dysglycemia and insulin resistance increase type 2 diabetes (T2D) and cardiovascular disease (CVD) risk, yet associations with specific glucose-insulin homeostatic biomarkers have been inconsistent. Vitamin D and marine omega-3 fatty acids (n-3 FA) may improve insulin resistance. We sought to examine the association between baseline levels of insulin, C-peptide, HbA1c, and a novel insulin resistance score (IRS) with incident cardiometabolic diseases, and whether randomized vitamin D or n-3 FA modify these associations.
View Article and Find Full Text PDFArticle Synopsis
- Physical activity (PA) both before and after a cancer diagnosis can lower the risk of mortality in cancer patients, as shown in studies involving large cohorts like the Women's Health Study and the Physicians' Health Study.
- Participants who remained active or became active after their diagnosis showed significantly lower risks for all-cause, cancer-specific, and non-cancer-related mortality compared to those who remained inactive.
- The findings suggest that encouraging physical activity in cancer patients might enhance survival, but further research is necessary to confirm these benefits across different types of cancers.
Background: Data on the relation of potato consumption with risk of type 2 diabetes (T2D) are limited and inconsistent. It is unclear whether the plant-based diet index (PDI), which is a novel and comprehensive tool to assess overall dietary pattern, modifies the association of potato intake with T2D.
Objectives: We examined the association of total, combined baked, boiled, and mashed potatoes and fried potatoes with risk of T2D and test the interaction between PDI score and potato consumption on T2D risk.
Background: High-sensitivity C-reactive protein (CRP), low-density lipoprotein (LDL) cholesterol, and lipoprotein(a) levels contribute to 5-year and 10-year predictions of cardiovascular risk and represent distinct pathways for pharmacologic intervention. More information about the usefulness of these biomarkers for predicting cardiovascular risk over longer periods of time in women is needed because early-life intervention represents an important risk-reduction method.
Methods: We measured high-sensitivity CRP, LDL cholesterol, and lipoprotein(a) levels at baseline in 27,939 initially healthy U.
Introduction: It is unclear whether moderate-to-vigorous physical activity (MVPA) is associated with a lower mortality risk, over and above its contribution to total physical activity volume.
Methods: 46,682 adults (mean age: 64 years) were included in a meta-analysis of nine prospective cohort studies. Each cohort generated tertiles of accelerometry-measured physical activity volume and volume-adjusted MVPA.
Objective: Accumulating more steps/day is associated with a lower risk of cancer mortality and composite cancer outcomes. However, less is known about the relationship of steps/day with the risk of multiple site-specific cancers.
Methods: This study included >22,000 women from the Women's Health Accelerometry Collaboration Cohort (2011-2022), comprised of women from the Women's Health Study and Women's Health Initiative Objective Physical Activity and Cardiovascular Health Study.
Article Synopsis
- This study investigates how different levels of physical activity can reduce the negative effects of sedentary behavior on mortality rates, particularly focusing on all-cause and cardiovascular disease (CVD) mortality.
- Researchers analyzed data from 73,729 adults using accelerometers to measure sedentary time and varying intensities of physical activity over roughly 6.9 years, identifying significant mortality outcomes.
- Findings suggest that engaging in at least 6 minutes of vigorous, 30 minutes of moderate-to-vigorous, 64 minutes of moderate, or 163 minutes of light physical activity daily can help mitigate the mortality risks associated with high sedentary time.
Importance: Higher adherence to the Mediterranean diet has been associated with reduced risk of all-cause mortality, but data on underlying molecular mechanisms over long follow-up are limited.
Objectives: To investigate Mediterranean diet adherence and risk of all-cause mortality and to examine the relative contribution of cardiometabolic factors to this risk reduction.
Design, Setting, And Participants: This cohort study included initially healthy women from the Women's Health Study, who had provided blood samples, biomarker measurements, and dietary information.
Background: Patterns of physical activity and sedentary behavior among postmenopausal women are not well characterized.
Objectives: To describe the patterns of accelerometer-assessed physical activity and sedentary behavior among postmenopausal women.
Design: Cross-sectional study.
Importance: Current US physical activity (PA) guidelines prescribe moderate to vigorous PA (MVPA) time of at least 150 minutes per week for health. An analogous step-based recommendation has not been issued due to insufficient evidence.
Objective: To examine the associations of MVPA time and step counts with all-cause mortality and cardiovascular disease (CVD).
Background: Describing correlates of physical activity (PA) and sedentary behavior (SB) among postmenopausal cancer survivors can help identify risk profiles and can be used to support development of targeted interventions to improve PA and reduce SB in this population.
Objective: To describe PA/SB and identify correlates of PA/SB among cancer and cancer-free post-menopausal women.
Methods: Women from the Women's Health Study (N = 16,629) and Women's Health Initiative/Objective Physical Activity and Cardiovascular Health Study (N = 6,079) were asked to wear an accelerometer on the hip for 7 days.
Context: Declining muscle strength and performance in older adults are associated with falls, fractures, and premature death.
Objective: This work aimed to determine whether supplementation with vitamin D3 or omega-3 fatty acids vs placebo for 2 years improves physical performance measures.
Methods: VITamin D and OmegA-3 TriaL (VITAL) was a double-blinded, placebo-controlled randomized trial of supplemental vitamin D3 and/or omega-3 fatty acids vs placebo in the prevention of cancer and cardiovascular disease in 25 871 US adults.
Article Synopsis
- The study aimed to understand how different types of physical activities, like walking and sitting, affect cardiometabolic health through a meta-analysis of data from over 12,000 adults.
- Results indicated that about 64 minutes of walking and 5 minutes of stair climbing per day, along with standing for about 2.6 hours, were linked to better cardiometabolic health scores, while running showed positive associations with health, without an upper limit for benefits.
- The analysis also found that sitting for more than 12.1 hours a day negatively impacted health scores, although this effect was less significant in people with existing cardiovascular issues or those on medication.
Objectives: This study aims to examine the associations of daily step count with all-cause mortality and incident cardiovascular disease (CVD) by sedentary time levels and to determine if the minimal and optimal number of daily steps is modified by high sedentary time.
Methods: Using data from the UK Biobank, this was a prospective dose-response analysis of total daily steps across low (<10.5 hours/day) and high (≥10.
Background: We examined the joint associations of diet and device-measured intensity-specific physical activity (PA) with all-cause mortality (ACM), cardiovascular disease (CVD), and cancer incidence.
Methods: We used data from 79,988 participants from the UK Biobank, a population-based prospective cohort study. Light PA (LPA), moderate-to-vigorous PA (MVPA), vigorous PA (VPA), and total PA (TPA) were measured using a wrist-worn accelerometer.
Background: Blueberries and anthocyanins, their key bioactive component, may improve eye health. However, few long-term studies have examined blueberries and anthocyanins with cataract and age-related macular degeneration (AMD).
Objectives: To investigate the prospective association between blueberry and anthocyanin intake with incident cataract, total AMD, and visually significant AMD among middle-aged and older women.