Publications by authors named "I-Hsien Lee"

While T-cell-mediated immune responses in solid tumors have been well-established and have driven major therapeutic advances, our understanding of B-cell biology in cancer is comparatively less developed. A total of 60 lung cancer patients were included, of which 53% were diagnosed at an early stage while 47% were diagnosed at an advanced stage. Flow cytometry was used to analyze the proportion of T and B cells in all blood samples, and the levels of human serum cytokines were also assessed.

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Monitoring ex-situ water parameters, namely heavy metals, needs time and laboratory work for water sampling and analytical processes, which can retard the response to ongoing pollution events. Previous studies have successfully applied fast modeling techniques such as artificial intelligence algorithms to predict heavy metals. However, neither low-cost feature predictability nor explainability assessments have been considered in the modeling process.

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  • This study focused on lung cancer patients requiring mechanical ventilation in the ICU, specifically those with non-small cell lung cancer (NSCLC) who have specific EGFR mutations and received EGFR-TKIs as their initial treatment.
  • Results showed a 77% survival rate in the ICU after 28 days, with a median overall survival of 67 days; however, certain factors like shock status and comorbidities significantly impacted survival and success in stopping ventilator support.
  • The findings suggest that EGFR TKIs can be beneficial for patients with certain mutations, particularly those without shock or diabetes, indicating a need for tailored treatments in critical care settings.
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Few studies have investigated the measurement of oxygen uptake ([Formula: see text]O) in tracheostomized patients undergoing unassisted breathing trials (UBTs) for liberation from mechanical ventilation (MV). Using an open-circuit, breath-to-breath method, we continuously measured [Formula: see text]O and relevant parameters during 120-min UBTs via a T-tube in 49 tracheostomized patients with prolonged MV, and calculated mean values in the first and last 5-min periods. Forty-one (84%) patients successfully completed the UBTs.

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  • * Key findings included the influence of groundwater flow direction, the presence of a shallow freshwater layer, and significant tidal fluctuations in water levels, which were all assessed through field experiments and model calibrations.
  • * The research concluded that the recharge rate is crucial for controlling the movement of contaminants from the waste site, with a suggested rate of 1000 mm/year needed to effectively manage plume travel to coastal areas.
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Objectives: Recurrent cholangitis may aggravate cholestatic liver cirrhosis in biliary atresia (BA) after the Kasai operation. This pilot study aimed to investigate whether Lactobacillus casei rhamnosus has the prophylactic efficacy for recurrent cholangitis in comparison with the conventional neomycin prophylaxis.

Methods: Twenty jaundice-free patients with BA ages 0 to 3 years who underwent a Kasai operation were enrolled and randomized into 2 groups with 10 patients each: neomycin (25 mg · kg · day for 4 days/wk) and L casei rhamnosus (8 × 10 colony-forming unit per day) groups.

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Objectives: The pathogenesis of biliary atresia (BA) is unclear, but epidemiological studies may help to elucidate possible causes. The goals of this study were to identify BA incidence changes in Taiwan in 2004-2009 and to survey the factors that might influence incidence changes to elucidate the possible causes of BA.

Methods: A Taiwan national registry system for BA has been established since 2004.

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  • Heavy metal-contaminated wastewater sludge from printed circuit board manufacturing is classified as hazardous waste and requires treatment to avoid environmental harm.
  • This study experimented with sulfuric acid in a batch reactor to remove heavy metals, finding that higher acid concentrations improved removal efficiency, while higher solid to liquid ratios decreased it.
  • The research developed a predictive mathematical model for sludge weight based on varying sulfuric acid concentrations and solid to liquid ratios, showing that trivalent heavy metals (like iron and chromium) were harder to remove than divalent ones, but over 99.9% removal was achieved with 0.5M sulfuric acid at a 5 g/L ratio in just 2 hours.
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The release of heavy metals from industrial wastewaters represents one of major threats to environment. Compared with chemical precipitation method, fixed-bed ion-exchange process can effectively remove heavy metals from wastewaters and generate no hazardous sludge. In order to design and operate fixed-bed ion-exchange processes successfully, it is very important to understand the column dynamics.

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Wastewaters containing heavy metals are usually treated by chemical precipitation method in Taiwan. This method can remove heavy metals form wastewaters efficiently, but the resultant heavy metal sludge is classified as hazardous solid waste and becomes another environmental problem. If we can remove heavy metals from sludge, it becomes non-hazardous waste and the treatment cost can be greatly reduced.

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  • The study aimed to explore factors influencing outcomes in children suffering from fulminant hepatic failure (FHF) related to hepatitis B virus (HBV) infection, analyzing 94 cases over a 14-year period in Taiwan.
  • It found a high overall mortality rate of 75%, with older patients and those with higher bilirubin levels having worse outcomes, while HBV-positive patients had better survival rates compared to HBV-negative patients.
  • The analysis revealed that in HBV-positive cases, prothrombin time was a key factor affecting mortality, whereas in HBV-negative cases, age and bilirubin levels were more critical for predicting survival.
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In order to remove and recover copper, zinc, cadmium, and chromium from the wastewater treatment sludge generated by an electroplating process, the heavy metal extraction kinetics was studied in a batch reactor using two different extraction agents (nitric and citric acid) at constant agitation speed (150 rpm) and solid to liquid ratio (10 g/L), but varying acid concentrations (0.02-0.10 N), temperatures (25-85 degrees C in nitric acid solution, 25-95 degrees C in citric acid solution), and sludge particle sizes.

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  • The study focuses on the prevalence of Helicobacter pylori (H. pylori) infection in children from 1989 to 1999 in the Chung Cheng District of Taipei city, examining how it has changed over the decade and comparing it to hepatitis A virus (HAV) transmission.
  • Results showed that by 1999, the overall H. pylori infection rate among children was 14.8%, with a noticeable rise after age 3, but no significant change was found compared to previous data from the 1980s.
  • The findings suggest that unlike HAV, H. pylori may have other transmission routes beyond the fecal-oral pathway, as the patterns of infection for the two diseases differed.
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We report on a 6 yr 7 m-old girl who had suffered from recurrent oral ulcers since July, 2000. Anal ulcers were also noted initially, and arthralgia was observed. Skin testing (pathergy test) showed only mild erythematous changes over the test area.

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To investigate the role of hepatitis B virus (HBV) infection in pediatric fulminant hepatic failure (FHF) after the launch of universal HBV vaccination, the authors analyzed the data from patients with FHF collected from a nationwide collaborative study group. Children aged 1 month to 15 years who were diagnosed with FHF (62 males and 33 females) between 1985-1999 were included. HBV infection (hepatitis B surface antigen [HBsAg] and/or immunoglobulin M hepatitis B core antibody [IgM anti-HBc] seropositive) accounted for 46% (43 of 95 cases) of all the cases of FHF.

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A 10-year-old girl with Rotor's syndrome was studied using Tc-99m di-isopropyl-iminodiacetic acid cholescintigraphy. The findings showed slow hepatic uptake, persistent cardiac blood pool radioactivity, and prominent renal excretion. The contribution of cholescintigraphy and pathophysiology will be discussed via a literature review.

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