Publications by authors named "I-Chi Hsu"
Article Synopsis
- The study focuses on octocorals, marine invertebrates known for producing cytotoxic substances, particularly two newly discovered prostanoids: clavulone I-15-one and 12-deacetylclavulone I, along with eleven known analogs.
- The structures of these new compounds were determined using advanced techniques like NMR, HRESIMS, and IR analysis.
- All tested prostanoids exhibited strong toxicity against the human oral cancer cell line Ca9-22, with clavulone I-15-one showing notable potency (IC value of 2.11 ± 0.03 μg/mL), and further analysis suggested their potential in cancer treatment.
Components with Anti-Diabetic Activity Isolated from the Leaves and Twigs of Collected in Vietnam.
Pharmaceuticals (Basel)
December 2022
A phytochemical investigation of the leaves and twigs of (Rutaceae), collected in Vietnam, yielded three new compounds named glyfuran (), glyphyllamide (), and glyphyllazole (), along with twenty-five known compounds (-). The structures of isolates were determined by IR, MS, NMR, and UV data analyses. In the anti-diabetic activity screening, (+)-isoaltholacton (), glycoborinine (), 2',4'-dihydroxy-4,6'-dimethoxychalcone (), and flavokawain A () simultaneously exhibited inhibition of dipeptidyl peptidase-4 (DPP4) and stimulation of the glucagon-like peptide-1 (GLP-1) secretion on the murine intestinal secretin tumor cell line (STC-1).
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