[Ultrastructural changes of myelinated fibers in the brain in continuous and attack-like paranoid schizophrenia].

Aim: Previously the authors have reported the ultrastructural pathology of myelinated fibers (MF) in the brain in schizophrenia. The aim of the present study was to compare the effect of disease course on ultrastructural changes of MF.

Material And Methods: Postmortem electron microscopic morphometric study of MF was performed in the prefrontal cortex, caudate nucleus and hippocampus in 19 cases of paranoid schizophrenia.

Thymus Polypeptide Preparation Tactivin Restores Learning and Memory in Thymectomied Rats.

We studied the effects of tactivin and splenic polypeptides on learning and memory of thymectomized animals. In 3-week rats, thymectomy blocked active avoidance conditioning. Injections of tactivin (0.

[The influence of the thymus peptides on analgesia caused by acute and chronic immobilization].

Objective: Our aim was to investigate the influence of thymic polypeptides on pain sensitivity and to analyze a possible role of the opioid system in the implementation of the analgesia caused by immobilization stress.

Methods: The study was performed on male Wistar rats at the Moscow state University named after M. V.

Stress-protective effect of thymic peptides.

Experiments on Wistar rats showed that thymic peptides produce a stress-protective effect that manifested in prevention of functional impairment of conditioned active avoidance response and a decrease in generalized motor activity typical of higher nervous activity failure. We concluded that thymic peptides significantly modulate integrative functions of the brain and produce a stress-protective effect.

[The impact of immunoactive drugs on passive avoidance response].

Aim: The objective of this project was to explore the influence of immunoactive drugs (tactivin, thymulin, and thymosin fraction 5) on the development of the passive avoidance conditioned reflex.

Materials And Methods: Two types of passive avoidance boxes were used--a regular two-chamber box and a modified three-chamber box, comprising a dark chamber in which rats were exposed to electrical shock, a safe dark chamber, and a light chamber in the center.

Results: The project has established that the memory trace persists longer under the influence of the immunoactive drugs in both models, which is consistent with the reference nootropic piracetam test results.