Publications by authors named "I Zapardiel"
Many clinicians recommend that patients diagnosed with HPV-related gynecologic cancers receive prophylactic HPV vaccination at the time of cancer diagnosis or after cancer treatment. In view of the large use of such practice, we aimed to assess the literature evidence supporting the use of prophylactic HPV vaccines after diagnosis or treatment of HPV-related gynecologic cancers. Women who develop HPV-related cervical, vaginal, and vulvar cancers represent a subgroup of patients who may be particularly sensitive to HPV infection and re-acquire infections.
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- - Uterine sarcomas with KAT6B/A::KANSL1 fusion are a new type of tumor that show a mix of traits from low-grade endometrial stromal sarcomas and smooth muscle tumors, which can confuse initial diagnoses.
- - A study involving 9 such cases found common features like expression of smooth muscle and endometrial stromal markers, as well as the presence of the KAT6B/A::KANSL1 fusion in all tumors.
- - Despite their bland appearance, these tumors can be aggressive, with some patients experiencing severe outcomes, underscoring the need for accurate recognition and diagnosis for better treatment approaches.
Objective: To assess the safety of fertility-sparing treatments for early-stage ovarian cancer in women younger than 40 years old.
Methods: We performed a retrospective multicenter study including women aged 18-40 years diagnosed with early-stage (FIGO I-II) ovarian cancer in 55 Spanish hospitals, from January 2010 to December 2019. Benign and borderline tumors were excluded, as well as advanced stages (FIGO III-IV).
Introduction: To evaluate the prognostic impact of substantial lymph vascular space invasion (LVSI) on the sentinel lymph node involvement and recurrence rate of patients with apparent uterine-confined endometrial cancer.
Materials And Methods: We enrolled consecutive patients with apparent confined endometrial cancer who underwent surgical staging with sentinel node mapping from 14 European reference centers. LVSI was analyzed semi-quantitatively, according to a 3-tiered scoring system classified as absent, focal, and substantial.