Publications by authors named "I Zahn"
Background: Metformin, a commonly prescribed medication for managing diabetes, has garnered increasing interest as a potential therapeutic option for combating cancer and aging.
Methods: The current study investigated the effects of metformin treatment on human meibomian gland epithelial cells (hMGECs) at morphological, molecular, and electron microscopy levels. HMGECs were stimulated in vitro with 1 mM, 5 mM, and 10 mM metformin for 24, 48, and 72 h.
Many plant transcription factors (TFs) are multifunctional and regulate growth and development in more than one tissue. These TFs can generally associate with different protein partners depending on the tissue type, thereby regulating tissue-specific target gene sets. However, how interaction specificity is ensured is still largely unclear.
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- The study investigates the potential of the lacrimal drainage system (LDS) as a way for SARS-CoV-2 to enter the body and cause infection, given its long tear contact time.
- Researchers analyzed human tear duct samples for the presence of ACE2 and other proteins involved in SARS-CoV-2 infection using various laboratory techniques.
- Findings revealed that all targeted receptors were present in the LDS, indicating it may serve as a path for the virus and suggests the need for careful consideration when applying medications to the eye.
The ocular system is in constant interaction with the environment and with numerous pathogens. The ATP-binding cassette (ABC) transporters represent one of the largest groups among the transmembrane proteins. Their relevance has been demonstrated for their defense function against biotic and abiotic stress factors, for metabolic processes in tumors and for their importance in the development of resistance to drugs.
View Article and Find Full Text PDFWhile the involvement of thermosensitive transient receptor potential channels (TRPs) in dry eye disease (DED) has been known for years, their expression in the meibomian gland (MG) has never been investigated. This study aims to show their expression and involvement in the lipogenesis of the MG, providing a possible new drug target in the treatment of DED. Our RT-PCR, Western blot and immunofluorescence analysis showed the expression of , , and in the MG at the gene and the protein level.
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