Publications by authors named "I Zaganas"
We examined associations between objective sleep duration and cognitive status in older adults initially categorized as cognitively non-impaired (CNI, = 57) or diagnosed with mild cognitive impairment (MCI, = 53). On follow-up, 8 years later, all participants underwent neuropsychiatric/neuropsychological evaluation and 7-day 24-h actigraphy. On re-assessment 62.
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- - Human evolution involved significant brain growth and unique cognitive abilities, marked by special adaptations in synaptic transmission and energy use in the brain.
- - A specific gene, hGDH2, evolved in our common ancestor with apes, enhancing glutamate metabolism and playing a key role in strengthening synaptic connections, notably in vital brain areas linked to cognition.
- - Research with transgenic mice shows that hGDH2 boosts synaptic plasticity and neuron-glia communication, which likely supports enhanced memory and complex cognitive functions in humans.
Glutamate dehydrogenase (GDH) interconverts glutamate to a-ketoglutarate and ammonia, interconnecting amino acid and carbohydrate metabolism. In humans, two functional GDH genes, and , encode for hGDH1 and hGDH2, respectively. evolved from retrotransposition of the gene in the common ancestor of modern apes.
View Article and Find Full Text PDFObjective: The purpose of this study was to evaluate the contribution of single photon emission computed tomography/computed tomography (SPECT/CT) standardized uptake value (SUV) metrics in classifying patients with suspected transthyretin cardiac amyloidosis (ATTR-CA) among the different Perugini grades.
Subjects And Methods: One hundred four patients suspected of ATTR-CA underwent planar scintigraphy with bone seeking tracer (Tc pyrophosphate-PYP). Patients were classified according to the Perugini scale, the H/CL, H/Bone and H/Bkg ratios.
Introduction: Although the link between sleep and memory function is well established, associations between sleep macrostructure and memory function in normal cognition and Mild Cognitive Impairment remain unclear. We aimed to investigate the longitudinal associations of baseline objectively assessed sleep quality and duration, as well as time in bed, with verbal memory capacity over a 7-9 year period. Participants are a well-characterized subsample of 148 persons (mean age at baseline: 72.
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