Publications by authors named "I Zafar"
The research is aimed at exploring the potential of marigold petal tea (MPT), rich in polyphenol contents, against oxidative stress and obesity in a rat model following a high-fat-sugar diet (HFSD). The MPT was prepared through the customary method of decoction and was subjected to analysis for its polyphenol composition using reversed-phase high-performance liquid chromatography (RP-HPLC). Two specific doses of MPT, namely, 250 and 500 mg/kg body weight (BW), were chosen for the study-referred to as MPT-250 and MPT-500, respectively.
View Article and Find Full Text PDFPreassembled complexes of hAgo2 and ssRNA delivered by nanoparticles: a novel silencing gene expression approach overcoming the absence of the canonical pathway of siRNA processing in the apicomplexan parasite Babesia microti, blood parasite of veterinary and zoonotic importance.
Emerg Microbes Infect
December 2025
Article Synopsis
- Current chemical drugs are ineffective for tick control and there are no effective vaccines, leading to the urgent need for new control strategies.
- Small interfering RNAs (siRNAs) have potential to help control parasites, but their effectiveness is limited by challenges in getting them to the RNA-induced silencing complex (RISC).
- This study developed a delivery system using chitosan nanoparticles to successfully transfect siRNAs into parasites, which reduced target gene expression and inhibited parasite growth, opening new avenues for gene therapy and understanding host-parasite interactions.
Article Synopsis
- * A study focused on seven consanguineous families with azoospermia from rural Pakistan utilized whole-exome sequencing (WES) to find genetic variants linked to this condition.
- * Researchers identified five harmful genetic variants across five families, contributing to the understanding of azoospermia's genetic basis, which could improve genetic counseling and lead to new treatments in the future.
This study aimed to assess the impact of enriching argan oil (AO) ( L.) using the maceration technique with thyme ( L.) and oregano ( L.
View Article and Find Full Text PDFDog owners are greatly concerned about tick infestations in their pets. The prevalence and dispersion of ticks and their disease-causing microorganisms have been limited from the viewpoint of dog owners in Vietnam. This study investigated the presence of tick infestation and the pathogens associated with it in canines that were brought to veterinary hospitals in Vietnam.
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