Glucocorticoid-induced osteonecrosis in systemic lupus erythematosus patients.

Osteonecrosis (ON) is a complex and multifactorial complication of systemic lupus erythematosus (SLE). ON is a devastating condition that causes severe pain and compromises the quality of life. The prevalence of ON in SLE patients is variable, ranging from 1.

[Depression of penicillin-evoked seizure discharges of cerebrospinal neurons by magnesium ions].

In experiments on narcotized spinal cats perfusion of the lumbosacral segments of the spinal cord with penicillin (50 mmol/l) containing artificial cerebrospinal fluid led to the appearance of spontaneous negative small potentials in the dorsal roots and spontaneous repetitive bursts of impulses in the ventral roots of the perfused segments. The epileptogenic activity of penicillin was reduced or completely blocked if administration of the penicillin containing cerebrospinal fluid was preceded by 20-30 minute perfusion of the central canal of the lumbosacral segments with cerebrospinal fluid containing a high concentration of magnesium ions.

[Effect of temperature on the spontaneous rhythmic activity of the neurons in the spinal centers of the frog lymphatic hearts].

Spontaneous rhythmic bursts of impulses were recorded from motoneurons related to posterior lymphatic hearts in 10th and/or 11th ventral roots of isolated frog spinal cord in vitro at the temperature of 1 degree C to 28 degrees C. The burst frequency varied from 10-12/min (at 1-3 degrees C) to 50-70/min (at 26-28 degrees C). The mean burst frequency for the 5-15 degrees C range was 2.

[Suppression of the dorsal root potentials of the cat spinal cord by manganese and cobalt ions].

In anesthetized spinal cats, perfusion of lumbosacral spinal cord with artificial CSF containing manganese (1.5-3.0 Mm/l) or cobalt (6.

[Furosemide depression of the dorsal root potentials and of the presynaptic inhibition of monosynaptic reflexes in the cat spinal cord].

In experiments on spinal narcotized cats perfusion of the lumbosacral cord through the central canal with artificial cerebrospinal fluid containing furosemide (15-48 mmol/l) led to the reversible selective depression of negative DRP and to the depression of prolonged "presynaptic" inhibition of extensor monosynaptic reflexes produced by volleys in flexor muscle afferents of group 1.