Publications by authors named "I Z Alajbeg"
Article Synopsis
- A case-control study examined SNP genotypes in 85 patients with pain-related temporomandibular disorders (TMDp) and 85 controls to find links between genetic factors and TMDp characteristics.
- The study found that individuals with high pain intensity were more likely to carry specific minor alleles (rs2227306 and rs2227307) compared to controls, indicating a potential genetic risk associated with pain levels.
- Logistic regression analysis identified minor allele "G" of rs2227307, older age, and female sex as significant predictors of high pain intensity, though genetic variations were not linked as risk factors for the overall presence of TMDp.
Objective: The aim was to design accessible, simple, inexpensive protection for teeth and soft tissues during ETI, compare damage occurrence with and without protection, and investigate post-ETI orofacial pain symptoms.
Materials And Methods: The selection procedure for adequate protection was carried out after which a reduced elastomer mouthguard was selected. Fifty patients were divided into 2 groups.
Article Synopsis
- The study investigates how specific genetic variations (SNPs) in the COMT and OPRM1 genes affect treatment responses in patients suffering from temporomandibular disorders (TMDp), particularly focusing on pain intensity, mouth opening, and anxiety levels.
- In a group of 60 TMDp patients who received standardized treatment over six months, those with minor allele variants showed less improvement in pain reduction and anxiety compared to those with dominant homozygous variants.
- The results suggest that genetic factors may help predict treatment outcomes in TMDp patients, implying that genotype assessment could be valuable in tailoring treatment strategies.
Purpose: To provide evidence-based recommendations for prevention and management of osteoradionecrosis (ORN) of the jaw secondary to head and neck radiation therapy in patients with cancer.
Methods: The International Society of Oral Oncology-Multinational Association for Supportive Care in Cancer (ISOO-MASCC) and ASCO convened a multidisciplinary Expert Panel to evaluate the evidence and formulate recommendations. PubMed, EMBASE, and Cochrane Library databases were searched for randomized controlled trials and observational studies, published between January 1, 2009, and December 1, 2023.
Article Synopsis
- The study aimed to investigate the release of opiorphin, an analgesic peptide, after stimulating the tongue with capsaicin, focusing on three groups: healthy individuals, those with Burning Mouth Syndrome (BMS), and individuals with painful Temporomandibular disorders (TMDp).* -
- Results showed that opiorphin levels were significantly higher in the TMDp group compared to healthy controls and that the BMS group showed increased levels after stimulation, indicating different pain response mechanisms among the groups.* -
- The findings suggest that understanding the regulation of opiorphin in orofacial pain conditions may offer clinical insights and the potential for further research in pain management.*