Asymmetric synthesis of spiro[oxindole-3,2'-pyrrolidine]s through organocatalytic 1,3-dipolar cycloaddition cycloreversion of precursor isatinimine homodimers.

The chiral amine catalyzed diastereo- and enantioselective [3 + 2] cycloaddition between isatin-derived azomethine ylides and α,β-unsaturated aldehydes was successfully carried out to afford spiro[oxindole-3,2'-pyrrolidine]s. It was anticipated that the formation of azomethine ylides occurred the cycloreversion of dispirooxindole-imidazolidines, which are precursor imine homodimers, in aqueous solvents.

In-Line Chemical Composition Monitoring for the Injection Molding Process of Biodegradable Polymer Blends Using Simultaneous Measurement of Near-Infrared Diffuse Reflectance and Transmission Spectra.

In the processing of polymer blends and composites, in-line near-infrared (NIR) spectroscopy enables monitoring of the composition and its composite uniformity and contributes to rapid process development and quality control. However, in the injection molding process, the study of the composition of polymer materials has been delayed due to high-pressure conditions. Our research group developed NIR probes for transmission and diffuse reflectance measurements that can withstand high-pressure and temperature conditions up to 130 MPa and 200 °C.

A case of refractory immune checkpoint inhibitor-induced colitis improved by the treatment with vedolizumab and granulocyte-monocyte apheresis combination therapy.

A 68-year-old man developed immune-related adverse event (irAE) colitis after the initiation of nivolumab and ipilimumab combination therapy for malignant melanoma. We diagnosed the patient with grade 3 irAE colitis and started prednisolone (1 mg/kg/day). Although the symptom improved once, it worsened along with the tapering of prednisolone.

Photoinduced Crystal-to-Liquid Transition of Acylhydrazone-Based Photoswitching Molecules.

A photoinduced crystal-to-liquid transition (PCLT) behavior of new acylhydrazone derivatives (NCs) is reported. The photoswitching of the NCs was identified as a negative photochromism with a high -to- conversion yield (>98%). A kinetic analysis shows a half-life of almost one month.