Whole genome sequencing characterization of Clostridioides difficile from Bulgaria during the COVID-19 pandemic.

Increased incidence of Clostridioides difficile infections were documented in Bulgarian hospitals during COVID-19. WGS was performed on 39 isolates from seven hospitals during 2015-2022. Antimicrobial resistance and toxin genes were inferred from genomes.

Comprehensive GC-MS Characterization and Histochemical Assessment of Various Parts of Three Species from Bulgarian Flora.

This study presents a comprehensive phyto- and histochemical analysis of three species: L., the Balkan endemic Guss., and the Bulgarian endemic Delip.

An Effective Methodology for Diabetes Prediction in the Case of Class Imbalance.

Diabetes causes an increase in the level of blood sugar, which leads to damage to various parts of the human body. Diabetes data are used not only for providing a deeper understanding of the treatment mechanisms but also for predicting the probability that one might become sick. This paper proposes a novel methodology to perform classification in the case of heavy class imbalance, as observed in the PIMA diabetes dataset.

Synthesis of Novel Benzothiazole-Profen Hybrid Amides as Potential NSAID Candidates.

Herein, we report the synthesis of a series of new compounds by combining 2-aminobenzothiazole with various profens. The compounds were characterized using techniques such as H- and C-NMR, FT-IR spectrometry, and high-resolution mass spectrometry (HRMS), with detailed HRMS analysis conducted for each molecule. Their biological activities were tested in vitro, revealing significant anti-inflammatory and antioxidant effects, comparable to those of standard reference compounds.