Publications by authors named "I Wolf"
Background: Cutaneous squamous cell carcinoma (cSCC) is characterized by a high tumor mutational burden due to solar damage and a favorable response to anti-PD-1 immunotherapy. Yet, we encounter tumors arising in areas with minimal sun exposure, such as cSCC that develops in chronically inflamed skin, also known as Marjolin's Ulcer (MU). The response of MU-SCC to immunotherapy remains unknown.
View Article and Find Full Text PDFEarth's obliquity and eccentricity cycles are strongly imprinted on Earth's climate and widely used to measure geological time. However, the record of these imprints on the oxygen isotope record in deep-sea benthic foraminifera (δO) shows contradictory signals that violate isotopic principles and cause controversy over climate-ice sheet interactions. Here, we present a δO record of high fidelity from International Ocean Drilling Program (IODP) Site U1406 in the northwest Atlantic Ocean.
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- As electronic devices get smaller and more complex, the effects of electromigration (EM) in interconnects become more significant, impacting their reliability and lifespan.
- This paper presents a simulation framework to study EM in nano-interconnects, focusing on how metal microstructure affects atomic flux and stress distribution due to diffusion variations.
- The study offers a novel method for creating realistic microstructures based on grain size data, advancing electromigration simulation by evaluating stress changes, void formation, and the effects of trench dimensions on copper interconnects, revealing optimal aspect ratios for extending EM lifetime.
Article Synopsis
- Patients with metastatic breast cancer often develop resistance to endocrine therapies, and in some cases, this is linked to mutations in the estrogen receptor-α (ESR1) that can lead to worse outcomes.
- Research using MCF-7 cells with common ESR1 mutations showed that these cells are more resistant to chemotherapy drugs, as evidenced by higher survival rates and lower levels of cell death compared to cells with wild-type ESR1.
- The study identified that the JNK/c-Jun/MDR1 pathway is involved in this chemoresistance, indicating that targeting this pathway may provide new treatment strategies for breast cancer patients with ESR1 mutations.
Background: Frailty constitutes a major factor that puts the elderly at risk of health and functional deterioration.
Objectives: To develop and validate an Electronic Frailty Index based on electronic data routinely collected in the HMO.
Study Design And Setting: A retrospective cohort of the HMO members.