Pharmacokinetics of terbutaline, a beta 2-sympathomimetic, in healthy volunteers and asthmatic patients.

The pharmacokinetics of 1-(35-dihydroxyphenyl)-2-(tert.butylamino)ethanol (terbutaline, Bricanyl) after i.v.

Pharmacokinetics of terbutaline after subcutaneous administration.

The pharmacokinetics of terbutaline has been studied after subcutaneous adminsitration of a therapeutic dose of 250 microgram in 14 patients. Short absorption half-lives of about 7 min resulted in a fast uptake of the drug. Serum concentrations of terbutaline were measured up to 10 hr after administration, depending on the individual.

Determination of terbutaline in post mortem human tissues by gas chromatography-mass spectrometry.

A method is described for the quantitative analysis of terbutaline in human tissues. Gas chromatography and chemical ionization mass fragmentography are used for selective and sensitive detection. A detection limit of 1.

The analysis of terbutaline in plasma and urine at therapeutic levels using mass fragmentography.

A sensitive method for the qualitative and semiquantitative determination of terbutaline in plasma and urine has been developed. After a single oral dose of 5 mg terbutaline sulphate the drug could be analysed easily. The detection limit in plasma is less than 1 ng ml-1.