Publications by authors named "I W Turnbull"
This paper presents a microneedle thermocouple probe designed for temperature measurements in biological samples, addressing a critical need in the field of biology. Fabricated on a Silicon-On-Insulator (SOI) wafer, the probe features a doped silicon (Si)/chrome (Cr)/gold (Au) junction, providing a high Seebeck coefficient, rapid response times, and excellent temperature resolution. The microfabrication process produces a microneedle with a triangular sensing junction.
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- Idiopathic Pulmonary Fibrosis (IPF) is a lung disease characterized by progressive scarring and currently lacks a cure, prompting the need for new therapeutic targets such as the cAMP pathway, particularly the protein Epac1.* -
- The study aimed to understand how Epac1 contributes to IPF progression by examining lung samples from IPF patients and preclinical models, alongside testing the effects of inhibiting Epac1 using a specific pharmacological agent, AM-001.* -
- Results showed that Epac1 levels were elevated in IPF tissue and fibroblasts, and inhibiting Epac1 led to reduced fibroblast proliferation and profibrotic signaling, indicating its potential role as a therapeutic target
Sepsis remains a leading cause of death worldwide with no proven immunomodulatory therapies. Stratifying Patient Immune Endotypes in Sepsis ('SPIES') is a prospective, multicenter observational study testing the utility of ELISpot as a functional bioassay specifically measuring cytokine-producing cells after stimulation to identify the immunosuppressed endotype, predict clinical outcomes in septic patients, and test potential immune stimulants for clinical development. Most ELISpot protocols call for the isolation of PBMC prior to their inclusion in the assay.
View Article and Find Full Text PDFBackground: Infectious diseases remain a major global health concern, including in China, with an estimated >10 million cases of infectious disease in 2019. We describe the burden of site-specific infectious diseases among Chinese adults.
Methods: From 2004 to 2008, the prospective China Kadoorie Biobank enrolled 512,726 adults aged 30-79 years from 10 diverse areas (5 rural, 5 urban) of China.
Sepsis results when a severe infection overwhelms the normal regulatory mechanisms of the immune system, resulting in a dysregulated host response characterized by new-onset organ failure. A wide range of infectious challenges can induce sepsis, resulting in an even wider range of maladaptive immune responses. This makes sepsis a syndromic diagnosis without a unifying, underlying molecular mechanism.
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