Publications by authors named "I W Brorson"
Article Synopsis
- The study investigates how common genetic variants related to breast cancer and other traits affect the immune environment in tumors (TIME) and responses to treatment.
- Researchers analyzed immune features from breast tumor samples and adjacent normal tissues of 825 breast cancer patients, identifying links between genetic risk scores and immune traits.
- Key findings include inverse relationships between genetic risk scores for inflammatory diseases and immune signaling, alongside positive associations for certain cell types, highlighting the connection between genetics and tumor immunity.
Understanding the contribution of immune mechanisms to Parkinson's disease pathogenesis is an important challenge, potentially of major therapeutic implications. To further elucidate the involvement of peripheral immune cells, we studied epigenome-wide DNA methylation in isolated populations of CD14 monocytes, CD19 B cells, CD4 T cells, and CD8 T cells from Parkinson's disease patients and healthy control participants. We included 25 patients with a maximum five years of disease duration and 25 controls, and isolated four immune cell populations from each fresh blood sample.
View Article and Find Full Text PDFBackground: Multiple sclerosis (MS) is an autoimmune, neurodegenerative disorder with a strong genetic component that acts in a complex interaction with environmental factors for disease development. CD4 T cells are pivotal players in MS pathogenesis, where peripherally activated T cells migrate to the central nervous system leading to demyelination and axonal degeneration. Through a proteomic approach, we aim at identifying dysregulated pathways in activated T cells from MS patients as compared to healthy controls.
View Article and Find Full Text PDFMultiple sclerosis (MS) is an autoimmune, neurological disease. We investigated genome-wide DNA methylation profiles of CD4 and CD8 T cells from MS patients and healthy controls at baseline and a follow-up visit. Patients were all treatment-naïve at baseline, and either on treatment or remained untreated at the follow-up visit.
View Article and Find Full Text PDFBackground: Genetic and clinical observations have indicated T cells are involved in MS pathology. There is little insight in how T cells are involved and whether or not these can be used as markers for MS.
Objectives: Analysis of the gene expression profiles of circulating CD8 T cells of MS patients compared to healthy controls.