Alterations in cardiac function correlate with a disruption in fatty acid metabolism in a mouse model of SMA.

Spinal Muscular Atrophy is an autosomal dominant disease caused by mutations and deletions within the SMN1 gene, with predominantly childhood onset. Although primarily a motor neuron disease, defects in non-neuronal tissues are described in both patients and mouse models. Here, we have undertaken a detailed study of the heart in the Smn2B/- mouse models of SMA, and reveal a thinning of the ventriclar walls as previously described in more severe mouse models of SMA.

Is Support in the Anxiety of the Beholder? How Anxiety Interacts with Perceptions of Instructor Support in Introductory Biology Classes.

High levels of student anxiety are negatively related to degree persistence, academic achievement, and student perceptions of instructor support. Anxiety levels vary along many axes-among classes, within students in the same class, and over time-creating a dynamic emotional landscape in classrooms. In this study, we examined the relationship between student anxiety levels and perceptions of instructor support within three introductory biology classes at two timepoints during a semester.

State-resolved modeling of electronic excitation in weakly ionized oxygen mixtures.

Electronic excitation and ionization in oxygen-argon mixtures are analyzed using a three-temperature electronic state-resolved model and evaluated using recent experimental data from reflected shock experiments. A detailed description of the model formulation and parameter selection is provided. Excellent agreement is obtained between model predictions and experimental measurements of O_{2} number density during dissociation in mixtures of 2%-5% O_{2} dilute in argon.

Sustained Decline of Direct General Practitioner Reporting of Adverse Drug Reactions in Australia and Paucity in Details of Australian Reports in Safety Advisories.

Introduction: There have been substantial changes in the nature of reporting pathways and review of suspected adverse drug reactions (ADRs) in Australia since the establishment of the now defunct Advisory Committee on Safety of Medicines early in 2010.

Objectives: The aim of this study was to (1) examine the reporting in Australia of suspected ADRs from various sources, including general practitioners (GPs), since 1990; (2) compare the reporting of Australian GPs with that in two other countries (New Zealand and the United Kingdom [UK]) with comparable safety monitoring programmes for the period 2007-2019; and (3) explore the extent to which Australian reporting of suspected adverse reactions has motivated communication to healthcare professionals in the period 1995-2019.

Methods: Annual reporting of sources of ADRs in Australia were obtained from Government reports, the Australian Statistics in Medicines and Therapeutic Goods Administration (TGA) websites.

Inequities in Rural and Urban Health Care Utilization Among Individuals Diagnosed With Inflammatory Bowel Disease: A Retrospective Population-Based Cohort Study From Saskatchewan, Canada.

Background: Rural dwellers with inflammatory bowel disease (IBD) face barriers to accessing specialized health services. We aimed to contrast health care utilization between rural and urban residents diagnosed with IBD in Saskatchewan, Canada.

Methods: We completed a population-based retrospective study from 1998/1999 to 2017/2018 using administrative health databases.