Application of film-casting technique to investigate drug-polymer miscibility in solid dispersion and hot-melt extrudate.

Determination of drug-polymer miscibility is critical for successful development of solid dispersions. This report details a practical method to predict miscibility and physical stability of drug with various polymers in solid dispersion and, especially, in melt extrudates by applying a film-casting technique. Mixtures of itraconazole (ITZ) with hydroxypropylmethylcellulose phthalate (HPMCP), Kollidon(®) VA 64, Eudragit(®) E PO, and Soluplus(®) were film-casted, exposed to 40°C/75% RH for 1 month and then analyzed using differential scanning calorimetry (DSC), powder X-ray diffractometry, and polarized light microscopy (PLM).

Effect of carbamazepine on viscoelastic properties and hot melt extrudability of Soluplus ®.

The purpose of this study was to apply viscoelastic properties of polymer and drug-polymer mixtures to determine processing conditions for the preparation of amorphous solid dispersion by melt extrusion. A poorly water-soluble drug, carbamazepine (CBZ), was mixed with Soluplus(®) as the carrier. Torque analysis using a melt extruder was performed at 10, 20 and 30% w/w drug concentrations and the effect of barrel temperature was studied.

[Surgical hand disinfektion with a solution of performic acid (author's transl)].

Disinfection with a solution of performic acid has an intensive bactericidal and sporocidal effect. This method is simple and prompt in service, is free from danger, inexpensive and can be used everywhere.