Physical and technological principles of creating biocompatible superparamagnetic particles.

Nanodisperse powder of zinc-substituted magnetite has been developed. Functional characteristics (biocompatibility, dispersion, magnetic state) allow to recommend it for approbation in medical and biologic technologies. The character of the temperature dependences of magnetization investigated in the magnetic fields lower than the anisotropy field indicates that transfer from the magnetically stable state into the superparamagnetic state was realized for particles of 3-13 nm in the temperature range of 4.

In vitro antioxidant profile of phenolic acid derivatives.

Several caffeic acid esters isolated from propolis exhibit interesting antioxidant properties, but their in vivo use is compromised by hydrolysis of the ester bond in the gastrointestinal tract. Therefore, a series of caffeic acid amides were synthesized and their in vitro antioxidant profile was determined. A series of hydroxybenzoic acids, hydroxycinnamic acids, and the synthesized caffeic acid amides were tested for both their 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging and microsomal lipid peroxidation-inhibiting activity.

Synthesis and evaluation of caffeic acid amides as antioxidants.

A series of amides of caffeic acid has been synthesised and their antioxidant properties evaluated as lipid peroxidation inhibitors. Anilides of caffeic acid were found to be very efficient antioxidants with IC50's of 0.3 microM.

Internal glucose residue loss in protonated O-diglycosyl flavonoids upon low-energy collision-induced dissociation.

The low-energy collision-induced dissociation of protonated flavonoid O-diglycosides, i.e., flavonoid O-rutinosides and O-neohesperidosides, containing different aglycone types has been studied.

Structure-activity relationship of diaryl phosphonate esters as potent irreversible dipeptidyl peptidase IV inhibitors.

The previously reported diphenyl 1-(S)-prolylpyrrolidine-2(R, S)-phosphonate (5) was used as a lead compound for the development of potent and irreversible inhibitors of dipeptidyl peptidase IV (DPP IV, EC 3.4.14.