Publications by authors named "I Van Mol"
Article Synopsis
- For patients with triple-class exposed/refractory multiple myeloma (TCE/RMM), B-cell maturation antigen and CD3-directed bispecific antibodies like teclistamab and elranatamab are emerging as new treatment options due to limited existing therapies.
- Teclistamab received conditional approval in Europe and accelerated FDA approval based on the MajesTEC-1 trial, while elranatamab was approved by the FDA following the MagnetisMM-3 trial.
- An indirect comparison showed that elranatamab outperformed teclistamab in terms of objective response rate and progression-free survival, suggesting it may be a more effective treatment for TCE/RMM patients.
Article Synopsis
- - Elranatamab, a new bispecific antibody targeting BCMA and CD3, was approved in August 2023 for treating triple-class exposed/refractory multiple myeloma (TCE/R MM) and showed promising results in the Phase 2 MagnetisMM-3 trial.
- - A matching-adjusted indirect comparison (MAIC) was conducted to evaluate elranatamab's effectiveness against physician's choice of treatment (PCT) by adjusting patient data from MagnetisMM-3 to real-world data from LocoMMotion and MAMMOTH studies.
- - Results indicated elranatamab significantly outperformed PCT, showing higher objective response rates, complete response rates, and longer
Objective: Brown adipose tissue (BAT) displays a strong circadian rhythm in metabolic activity, but it is unclear how this rhythm is regulated. As circulating levels of corticosterone coincide with the rhythm of triglyceride-derived fatty acid (FA) uptake by BAT, we investigated whether corticosterone regulates BAT circadian rhythm.
Methods: Corticosterone levels were flattened by implanting mice with subcutaneous corticosterone-releasing pellets, resulting in constant circulating corticosterone levels.
Background: C-type lectin receptors, including Dectin-2, are pattern recognition receptors on monocytes and macrophages that mainly recognize sugars and sugar-like structures present on fungi. Activation of C-type lectin receptors induces downstream CARD9 signalling, leading to the production of cytokines. We hypothesized that under hyperglycaemic conditions, as is the case in diabetes mellitus, glycosylated protein (sugar-like) structures activate C-type lectin receptors, leading to immune cell activation and increased atherosclerosis development.
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- Researchers investigated the roles of brain mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs) in the hippocampus, focusing on how they respond to stress.
- The study identified specific genes targeted by MRs that show altered expression in mice lacking these receptors, particularly a significant decrease in the gene Jun dimerization protein 2 (Jdp2).
- This suggests that MRs have unique regulatory roles in gene expression related to stress response, with Jdp2 potentially serving as a critical MR target influenced by acute stress.