Influence of exogenous lactoferrin on the oxidant/antioxidant balance and molecular profile of hormone receptor-positive and -negative human breast cancer cells in vitro.

Aim: To investigate the mechanisms of cytotoxic activity and pro-/antioxidant effect of lactoferrin on hormone receptor-positive and receptor-negative breast cancer cells in vitro.

Materials And Methods: The study was performed on receptor-positive (MCF-7, T47D) and receptor-negative (MDA-MB-231, MDA-MB-468) human breast cancer cell lines. Immunocytochemical staining, flow cytometry, low-temperature electron paramagnetic resonance, and the Comet assay were used.

Modifying effects of lactoferrin in vitro on molecular phenotype of human breast cancer cells.

Aim: To assess the role of endogenous lactoferrin (LF) in the formation of the molecular phenotype of human breast cancer (BC) cell lines with varying degrees of malignancy, including cisplatin/doxorubicin resistant cell lines, and identify possible impact of exogenous LF.

Materials And Methods: 5 breast cell lines of different origin - MCF-10 A, MCF-7, including doxorubicin/cisplatin resistant ones, T47D, MDA-MB-231, and MDA-MB-468. Immunocytochemistry: expression of LF, Ki-67, adhesion molecules E- and N-cadherin, CD44, CD24 rating the invasive potential of cells.

[Risk of fatal postoperative pulmonary embolism in cancer patients].

A retrospective study included 100 cancer patients who had died of fatal pulmonary embolism (PE) in the postoperative period. Assessment of the hazard of fatal postoperative PE demonstrated that the risk peaked on day 7 after operation and later on gradually diminished. The first three postoperative weeks featured high risk of fatal PE development as 90% of deaths were registered during its course.

[Influence of psychological and psychopathological features of cancer patient personality on their attitudes towards the disease].

Our paper deals with psychological and psychopathological features of cancer patient personality. Our data deals with on influence of such characteristics on attitudes of cancer patients towards the disease. The impact of pre-morbid features of patients on their attitudes was established.