[The role of nutrigenetics and nutrigenomics in the prophylaxis of chronic non-communicable diseases].

Over the past several decades there has been an increase in the number of chronic noncommunicable diseases worldwide largely due to changes in diet and lifestyle, as well as exposure to adverse environmental factors. The so-called omics technologies (genomic, proteomic, metabolomic and transcriptomic) are used as tools for comprehensive analysis and monitoring of human health. Currently, genomic and post-genomic technologies are used to study the effects of various nutrients on human health.

[The prevalence of gastroesophageal reflux disease in agricultural workers].

Among agricultural workers is common gastroesophageal reflux disease. On a professional factors affecting agricultural labor (physical activity, weight lifting, carrying heavy loads, frequent and/or long slopes). These factors contribute to the development of gastroesophageal reflux disease and severe course.

HeLa cells cocultured with peripheral blood lymphocytes acquire an immuno-inhibitory phenotype through up-regulation of indoleamine 2,3-dioxygenase activity.

The mechanisms by which tumour cells escape recognition by the immune system or subvert antitumour effector responses remain poorly understood. In the course of investigating the potential of costimulatory signals in anticancer immunotherapy strategies, we have observed that HeLa cells (a human cervical carcinoma cell line) cocultured with peripheral blood lymphocytes (PBL) acquire the capacity to inhibit PBL proliferation in response to interleukin-2 (IL-2). This immuno-inhibitory phenotype was further shown to result from induction of the tryptophan-catabolizing enzyme, indoleamine 2,3-dioxygenase (IDO), by interferon-gamma (IFN-gamma) secreted from cocultured allo-reactive PBL.

Low molecular mass phosphoproteins from the frog rod outer segments form a complex with 48 kDa protein.

Upon separation of cAMP-dependent low molecular mass phosphoproteins [Components I and II; Polans et al. (1979) J. gen.

[The choice of the method for restoring gastrointestinal tract continuity in gastric resection for peptic ulcer].

Resection of the stomach was carried out in 299 patients (in 151 for gastric ulcer and in 148 for duodenal ulcer). The method for restoring the continuity of the gastrointestinal tract after gastric resection was individualized according to the location of the ulcer, the patient's age, the character of complications of peptic ulcer, the topographoanatomical conditions in the zone of the operation, and the motility and acid-producing activity of the stomach. The indications and contraindications for various types of gastrointestinal anastomoses are discussed.