[MORPHOLOGICAL CHANGES IN RAT MYOCARDIUM EXPOSED TO HEMIC HYPOXIA AND TREATED WITH CYTOFLAVIN.].

This study was aimed at determining the influence of cytoflavin on the morphological features of contractile cardiomyocytes in female rats after gestation and in newborn rats exposed to hemic hypoxia induced by sodium nitrite (NaNO(2)). The experiment was performed on 28 three-month-old female Wistar albino rats and their offspring (24 seven-day-old newborns). Throughout pregnancy and during 7 days of suckling period, all animals divided into two groups were daily injected intraperitoneally with NaNO(2) at a dose of 5 mg/100 g body weight.

[Investigation of the antioxidant activity and cardioprotective effect of reamberin and cytoflavin in newborn rats exposed to chronic hemic hypoxia].

The authors analyzed the antioxidant activity of reamberin and cytoflavin and evaluated their cardioprotective effect, by investigating lipid peroxidation and oxidative modification of plasma proteins, as well as the ultrastructure of newborn rat cardiomyocytes under chronic hemic hypoxia induced by sodium nitrite. Reamberin and cytoflavin can reduce the manifestations of mitochondrial dysfunction and the degree of cardiomyocyte damage in the neonatal rats due to the antioxidant and membrane-protective properties of the drugs. Succinic acid in combination with the metabolic components of the drugs significantly inhibits lipid peroxidation, by improving the structure of membranes and the mitochondrial function of cardiomyocytes.