Study of drug transport between the blood and lymph in the predominant direction.

Our method for evaluating the time course and intensity of antibiotics and other drugs transport in the predominant direction between the blood and lymph in humans promotes a more objective evaluation of drug circulation mechanisms, which is essential for determining the time of their repeated administration and route of administration. Calculation of the lymph/blood difference coefficient, based on parallel repeated measurements of the drug concentration in the lymph and blood, and of the lymph/blood coefficient provides complete data on the direction and time course of drug transport between the lymph and blood in the predominant direction.

Mathematical model of little invasive interventions on the hollow organs using traditional and shape memory Ni-Ti-based biocompatible superelastic materials.

Comparative analysis of the mode of deformation of hollow organs (extrahepatic bile ducts at the site of stricture) was carried out by the finite elements method during interventions in the lumen using stone extraction Dormia basket made of stainless steel and NiTi. Geometrical and physical models of the ducts and basket were created, strain and deformation fields in the choledochal walls were determined, criteria of traumaticity and medical technological requirements to the material and geometry of lithoextractors were formulated.

Experimental study of the use of Perftoran for preventing the formation of postoperative adhesions in peritonitis.

The effect of Perftoran (perfluorocarbon compound) on cells of the peritoneal exudate and small intestinal serosa was studied in Wistar rats with experimental peritonitis and mechanical injury. The peritoneal cavity was treated with Perftoran for preventing postoperative adhesions and the mechanisms of reparative regeneration of the mesothelium after this treatment were studied by immunohistochemical methods and scanning electron microscopy. The increase in macrophage population during the early postoperative period and its decrease at later terms prevented fibroblast activation and promoted epithelialization as early as by day 5.