[Comparative analysis of the influence of nano- and ionic forms of silver on biochemical indices in laboratory animals].

A comparative analysis of the effect of silver nanoparticles (SNP) with a diameter of 14 nm and silver sulfate (SS) on biochemical indices of the state of the organism under the administration of preparations with drinking water to mice F1 CBAxC57Bl (from 0.1 to 500 mg Ag/l for 2 weeks) and nonlinear rats (from 0.01 to 5 mg Ag/l within 6 months) has been performed In the experiment on mice there was found an increase in activity of glutathione reductase (GR) in erythrocytes under the administration of both drugs and reduction of antiradical activity of serum--under the introduction of SNP only.

[Changes in the cytokine profile in residents with chronic obstructive lung disease exposed to urban air pollutants].

The complex of urban air pollutants was established to affect the cytokine profile in Moscow residents with chronic obstructive pulmonary disease (COPD)), as it causes a significant reduction of L-6 and TNF-alpha in their blood samples. The identified changes indicate to inhibition of the functional activity of cells of the reticuloendothelial system, which can lead to the persistence of seasonal bacterial-viral infections and more rapid chronization of the basic disease.

[Testing of the system of biochemical and immunological indices of the state of population health in the survey of residents of Moscow, exposed to ambient air pollution].

New biomarkers of effect of some controlled ambient air pollutants (formaldehyde, carbon monoxide and TSP) were found in two surveys of Moscow residents (apparently healthy and outpatients with allergic diseases) with a help of screening system of biochemical and immunological parameters. Possible mechanisms of the effects, including interference of atmospheric carbon monoxide and sulfur dioxide with corresponding endogenous second messengers, are discussed.

[Dependence of protective effect of alpha-tocopherol on its concentration and time of action on PC12 cell under conditions of oxidative stress].

At the short-term incubation (0.5 and 1.5 h) of cells of the PC12 neuronal line with alpha-tocopherol, its protective effect against the cytotoxic hydrogen peroxide action was increased with rise of its concentration in samples; the protection was practically absent at action of nanomolar antioxidant concentrations, but was well expressed at its micromolar concentrations.