Publications by authors named "I V Troshina"

Article Synopsis
  • A study analyzed the genetic variants rs7903146 of the TCF7L2 gene and rs1801282 of the PPARG gene in 64 Tyumen citizens aged 40-70, focusing on their relationship with metabolic parameters and insulin resistance.
  • The researchers found that homozygous carriers of the C allele for rs7903146 had higher C-peptide levels and associations with increased waist circumference, elevated glycated hemoglobin, and hypertension.
  • For the rs1801282 variant, homozygous carriers of the C allele showed higher triglyceride levels and similar associations with waist circumference and glycated hemoglobin compared to other genotypes.
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The review presents the literature data on the effect of the nutrition of women on the course of pregnancy and the condition of a fetus. The mother's body during pregnancy is the only source of nutrients for a developing fetus. The woman's nutrition before and during pregnancy affects not only her own health and the development of a fetus, but can also results in the risk of non-infectious diseases and obesity among their children throughout their lives.

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The literature on the place and role of insomnia in cerebral blood circulation disturbances is reviewed. It is emphasized that insomnia is a modifying risk factor of cerebrovascular pathology. The syndrome of obstructive sleep apnea may be a cause of arterial hypertension.

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Aim: To study levels of systemic inflammation markers and plasminogen activator inhibitor-1 (PAL-1) in patients with metabolic syndrome (MS) and establish their relationship with the progress of selected stages of non-alcoholic fatty liver disease (NAFLD).

Materials And Methods: 129 patients aged 18-59 yr with abdominal obesity and MS underwent elastometry for the assessment of the degree of fibrosis depending on concomitant metabolic disorders and measurement of proinflammatory cytokine levels.

Results: Disorders of carbohydrate metabolism in MS patients are associated with the high levels of systemic inflammation markers (CRP, TNF-α, IL-6) and a two-fold rise in the PAI-1 level.

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The paper analyzes an association between occupational risk factors in the female workers of greenhouses and allergic diseases in their children. The major factors contributing to the occurrence of allergic disease in children are their maternal employment in greenhouses with harmful working conditions, much dust in an apartment, a family history of allergic diseases, and unfavorable family lifestyle.

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