Fostered offspring develop hyper-reactive endocrine stress responses in a plural-breeding rodent, Octodon degus.

Long-term parental separation can lead to altered behavioral and physical development in human children. Rodent models are popular for studying parent-child separation, and several studies have found that maternal separation leads to chronic changes in the endocrine stress response. However, while human children are generally raised by multiple caregivers, most rodent studies utilize solitary breeding species.

[The mechanisms of the effect of serotonin on the prostacyclin synthesis and coronary vascular resistance of the isolated rat heart].

An early reduction of coronary vascular resistance after serotonin administration was found to be due to the activity of prostacyclin synthesis and an endothelial-relaxing factor in the rat isolated heart. The activating effect of serotonin on the prostacyclin synthesis was inhibited by catanserin and dyltyasem. The latters prevented damage of endotheliocytes and the beginning of a vasal constriction caused by the protracted serotonin action.

[The cholesterol and lysophospholipid content of the plasma and blood cells in patients with stable stenocardia of effort].

A study of 13 patients with stable exertion stenocardia and a positive bicycle ergometry [correction of veloergometric] test revealed an activation of the thrombocytic lysoform factors (lyso-FAT) along with reduction of cholesterol lipoproteids of density activity of lecithincholesterolacyltranferase. Increase of lyso-FAT is associated with accumulation of cholesterol and lysophosphatidylcholine in thrombocytes and erythrocytes. The participation of lyso-FAT in the pathogenesis of stable exertion stenocardia is suggested.