[T-specific D17Leh66 DNA elements in family Muridae].

Blot-hybridization analysis with the use of the t-specific probe D17Leh66 has been used to study DNA of various representatives of family Muridae. Hamsters from genus Phodopus have no homologs of this probe, whereas African rats from genus Lophuromys have some homologous elements. This indicates that sequence Dl7Leh66 is ancient and was probably present in the common ancestor of family Muridae.

[Genetic and molecular characteristics of a new natural haplotype twMP1 of the house mouse (Mus domesticus R.) from Peru].

A new natural haplotype, twWP1, found in a population of house mouse Mus domesticus from Peru, was subjected to genetic and molecular analyses. Experiments were performed to study the complementation of the new haplotype, fertility of twMP1/tx heterozygotes, and transmission ratio distortion (TRD) of the t-carrying chromosome in the progeny of heterozygous males. Molecular analysis included blot hybridization with t-specific probes Tu48, Tu66, and Tu119.

[Structural organization and evolution of t-complex in Mus genus].

Modern data on the structure and evolution of the t complex are discussed. The t complex is a series of inversions in the proximal region of murine chromosome 17; it contains a set of genes that determine its predominant transmission to the offspring of heterozygous males. Variants of structural organization of this genetic system (t haplotypes) have been found in wild populations of four species of genus Mus (M.

[Characterization of a novel wild-type t(wMPI) haplotype of the house mouse (Mus domesticus L.) from Peru].

Data on molecular genetic analysis of the novel wild-type twMP1 haplotype found in a population of Mus domesticus from Peru are presented. Complementation attribution of the novel haplotype as well as fertility of heterozygotes and transmission ratio distortion (TRD) of the t-carrying chromosome in the progeny of the heterozygous males were studied. Molecular analysis was carried out by means of blot hybridization with the four t-specific probes (Tu48, Tu66, Tu119, and Tu122).

[Effect of an increased radiation background on mice, carrying lethal t-haplotypes].

To study the effect of a high radiation background on the structure and function of the T-complex, we used laboratory mice carrying t-haplotypes of four complementation groups (t0, t12, tw1, and tw5). In 1987-1989, the animals were kept each year for a month within a 30-kilometer zone of Chernobyl Nuclear Power Station in regions with different degrees of pollution. Subsequent genetic analysis revealed a decrease in fertility, fecundity, and the index of preferable transmission of t-carrying chromosomes in radiated animals and some of their progeny.