Revised McDonald criteria for multiple sclerosis diagnostics in central Russia: sensitivity and specificity.

Background: The 2010 revised McDonald criteria were developed with data gathered from Caucasian European and North American populations, and their applicability has been questioned for the Russian population.

Objective: The objective of this report is to compare the specificity, accuracy, sensitivity and predictive value of MRI criteria incorporated to the new (2010) and old (2005) McDonald criteria for early multiple sclerosis (MS) diagnostics in the Nyzhnyi Novgorod (Russia) population.

Methods: A total of 103 patients with symptoms suggestive of MS were recruited from 2008 to 2011 retrospectively.

[Possibilities of using the 2010 McDonald criteria for early diagnosis of multiple sclerosis].

Revised 2010 McDonald criteria for multiple sclerosis (MS) give possibility for early diagnosis using magnetic resonance imaging (MRI) and, in some cases, allow to establish a confirmed diagnosis of MS even after the first referral that is very important for timely diagnosis. However the new criteria should be tested in different samples of patients. The aim of our work was to evaluate the ability to use the new McDonald criteria in the Nyzhegorodsky population.