Publications by authors named "I V Sergeeva"
Two novel HLA-С alleles HLA-C*07:1153 and -C*07:1154 alleles detected during routine next generation sequencing.
View Article and Find Full Text PDFIntroduction And Aims: Observational studies have reported conflicting associations between periodontitis (PD) and hepatocellular carcinoma (HCC). To overcome these limitations, we performed a two-sample Mendelian randomization (MR) analysis to investigate the potential association between PD and HCC.
Methods: We used summary data from genome-wide association studies (GWASs) of European ancestry, integrating data from chronic/acute periodontitis (CP/AP) samples (n1 = 34,615; n2 = 277,036; n3 = 410,811) and HCC samples (n1 = 456,348; n2 = 475,638).
Article Synopsis
- - The study explores how quercetin (Que) was encapsulated using composite nanoparticles made of zein and soy protein isolate (SPI) for regulated release during digestion, employing an antisolvent precipitation method.
- - The composite nanoparticles achieved an average size of 182.1 to 230.9 nm and demonstrated a high encapsulation efficiency of 93.3%, while their microstructure showed spherical distribution with Que embedded on their surface.
- - Enhanced release of Que was observed with the composite nanoparticles during simulated gastrointestinal digestion compared to single zein nanoparticles, indicating a promising approach for developing controlled-release drug delivery systems.
Human papillomavirus (HPV) infections are an increasing cause of oropharyngeal squamous cell carcinomas (OPSCC). Integration of the viral genome into the host genome is suggested to affect carcinogenesis, however, the correlation with OPSCC patient prognosis is still unclear. Research on HPV integration is hampered by current integration detection technologies and their unsuitability for formalin-fixed paraffin-embedded (FFPE) tissues.
View Article and Find Full Text PDFBackground: Liver ischemia-reperfusion injury (LIRI) is closely associated with immune infiltration, which commonly occurs after liver surgery, especially liver transplantation. Therefore, it is crucial to identify the genes responsible for LIRI and develop effective therapeutic strategies that target immune response. Methylation modifications in mRNA play various crucial roles in different diseases.
View Article and Find Full Text PDF