[Pneumocystosis in mice under the conditions of a secondary immunodeficiency and with specific immunological tolerance for Pneumocystis carinii].

To study pneumocystosis and to develop the method of its reliable diagnosis, two mouse models of this disease were created. In model 1 mice with T helpers eliminated by means of monoclonal antibodies (McAb) to T-cell marker L3T4 were used. For this purpose mice were injected intraperitoneally with McAb and then infected with P.

[Monoamine oxidase activity in gastrointestinal tract tissues of animals after irradiation and administration of pyridoxal phosphate].

The X-ray irradiation in a dose of 450 R is shown to decrease the monoaminoxidase activity in the cell fractions of the mucous membrane of small intestine as against the fractions of the stomach mucosa. The administration of pyridoxalphosphate to the irradiated rabbits increases the monoaminoxidase activity in the fraction and subfractions of small intestine mucosa mitochondria, but the enzyme activity being compared with the control group has a tendency to decrease.

[Increase in 5'-nucleotidase and decrease in guanylate kinase activity in the brain and liver of irradiated rats].

The activity of 5-nucleotidase (EC 3.1.3.

[Changes in the brain GABA system after repeated injections of pyridoxal-5'-phosphate and its Schiff base with GABA].

A state of the gamma-aminobutyric acid (GABA) system (glutamate, glutamate decarboxylase, GABA, GABA-alpha-ketoglutarate aminotransferase) and the coupled reactions (alpha-ketoglutarate dehydrogenase complex, aspartate- and alanine aminotransferases) was studied in three brain structures (cerebellum, brain cortex and truncus cerebri) after multiple administration of pyridoxal-5'-phosphate (PALP) and its Shiff base with GABA (5 injections at doses 10.0 and 15.0 mg/kg of body mass, respectively).

[Changes in the level of pyrimidine nucleoside phosphates in the liver of irradiated rats].

Content of uridyl and cytidyl nucleoside-phosphates in the liver of rats irradiated by gamma-rays (60Co) in a dose of 774 mC/kg (3000 P) was studied 0.5, 1, 3, 6 and 24 h after the effect. A trustworthy decrease of UTP and CTP as well as UDP and CDP content 24 h after irradiation was found.