[Postresuscitation cerebral structural and functional changes associated with the initial type of behavior].

The elevated cross-shaped labyrinth test carried out on highly, moderately, and low active experimental animals revealed significant differences in the baseline density and composition of neuroglial populations of numerous formations of the brain, as well as in the early structural and functional sequels of experienced clinical death. The most pronounced postresuscitation abnormal changes were observed in highly active animals and the least marked ones were seen in moderately active animals.

Active and passive behavior of animals during the postresuscitation period.

Behavioral reactions (open-field test, elevated plus-maze, pain stress, and feeding behavior) were studied in various periods after clinical death caused by circulatory arrest for 10 or 15 min. We revealed two different phases of behavioral changes: active behavior directed at attaining a specific goal and passive behavior directed towards isolation of the organism from external signals and functional minimization. Active behavior determined by pathological excitation in the central nervous system increased the severity of structural damage to hippocampal CA1 neurons during the postresuscitation period.

[Development of postresuscitation morphological changes of hippocampal and cerebellar neurons: common regularities and specific features].

A comparative morphometric study of postresuscitation changes in the neuronal populations of the pyramidal cells from hyppocampal sector CA1 and Purkinje cells of the lateral cerebellar region in the course of postresuscitation period after 12-minute cardiac arrest in rats has shown that the changes differ in severity and pattern. In the pyramidal cells there were reversible dystrophic alterations of the neurons. Purkinje cells showed death of some neurons, this process progressed in the course of postresuscitation period.

[Therapy of postresuscitation behavioral disorders with mexidol and kyotorphin].

A complex of behavioral tests revealed diminished anxiety, increased locomotor and exploratory activities, and changes in different learning tests in resuscitated animals. Mexidol alone and in combination with kyotorphin exhibited antistressogenic and nootropic activities, and led to a compensation of ischemic lesions in rats. It can be stated that a the injection of mexidol in combination with kyotorphin yielded better results due to its neuroprotective effect in the CA1 and CA4 fields of the hippocampus.

[Effect of perftoran on post-resuscitation recovery of the central nervous system].

The effect of perfluorane on survival and restorative process in the brain were studied in rats subjected to 12-min arrest of systemic circulation. Perfluorane in a single dose of 5-10 ml/kg was injected intraperitoneally 30 min after the beginning of reanimation. The drug did not affect the postreanimation death of animals and time course of neurologic deficiency disappearance.