Publications by authors named "I V Pozhidaev"
Metabolic syndrome (MetS) is common among schizophrenia patients, and one of MetS's causes may be an imbalance in nitric oxide regulation. In this study, we examined associations of three polymorphic variants of the nitric oxide synthase 1 adapter protein () gene with MetS in schizophrenia. NOS1AP regulates neuronal nitric oxide synthase, which controls intracellular calcium levels and may influence insulin secretion.
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- - The study explores how genetic variations influencing the glutamatergic neurotransmitter system impact the development and clinical symptoms of schizophrenia in 805 Russian patients from Siberia.
- - Three specific gene variants (rs11644461, rs8057394, rs7313149) are linked to a particular type of schizophrenia, with the rs8057394*G allele identified as a risk factor for this type.
- - Additionally, another variant (rs62126236) shows a protective effect against negative symptoms, while overall symptom severity is significantly associated with yet another variant (rs9788936), indicating the role of genetic factors in schizophrenia's clinical diversity.
Article Synopsis
- Metabolic syndrome is common among schizophrenia patients on long-term antipsychotic treatment, which can result from the effects of dopamine D2 receptors.
- The study analyzed 517 schizophrenia patients in Siberia, focusing on two specific genetic variations in the DRD2 gene and their link to metabolic syndrome.
- Findings suggest that a particular variation (rs1799732) is associated with drug-induced metabolic syndrome in women, pointing to the potential for targeted genetic treatments to improve patient outcomes.
Background: Tardive dyskinesia (TD) is an extrapyramidal side effect of the long-term use of antipsychotics. In the present study, the role of glutamatergic system genes in the pathogenesis of total TD, as well as two phenotypic forms, orofacial TD and limb-truncal TD, was studied.
Methods: A set of 46 SNPs of the glutamatergic system genes (, , , , , , , , ) was studied in a population of 704 Caucasian patients with schizophrenia.
Background: Metabolic syndrome (MetS) is a common complication of long-term treatment of persons with schizophrenia taking (atypical) antipsychotics. In this study, we investigated the existence of an association with polymorphisms of genes for four hormones that regulate energy metabolism.
Methods: We recruited 517 clinically admitted white patients (269M/248F) with a verified diagnosis of schizophrenia (ICD-10) and with a stable physical condition.