[Study of surface-active properties antivirials compound 1-boraadamantane for model monomoleculars phosphlipids layers].

The surface-active properties of 1-boraadamantane have been studied using model phospholipid monolayers. Results suggest that the increase in 1-boraadamantane concentrations from 10(-7) to 10(-6) M is accompanied by the increase of the area per phospholipid molecule. This decreases to frequency of lateral diffusion of phospholipids molecules, the potential difference and the angle of the phospholipid monolayer arrangement.

[The study of structural changes in influenza virus hemagglutinin (HA) after interaction with liposomes by the fluorescence method].

Using the method of self fluorescence quenching influence of phospholipids on conformational state of HA has been studied. Interactions of HA with model phospholipids membranes are accompanied by changes of structure-dynamic protein organization. This method could be used for controlling the structure organization of proteins after receiving by virus the influenzal virusomal vaccine.