Publications by authors named "I V Pinchuk"
Telocytes, a novel mesenchymal cell population, are characterized by their distinctive long and slender projections known as telopodes and have garnered significant interest since their formal introduction to the literature in 2010. These cells have been identified in various tissues, including the gastrointestinal (GI) tract, where they are suggested to play important roles in maintaining structural integrity, immune modulation, and barrier function. Inflammatory bowel diseases (IBD), which include Crohn's disease (CD) and ulcerative colitis (UC), are characterized by chronic inflammation and fibrosis.
View Article and Find Full Text PDFBiodegradable mulching films offer an eco-friendly alternative to petroleum-based plastics in agriculture, but their effects on soil parameters are not well understood. A microcosm experiment (20 °C, 75% field capacity) investigated the impact of two doses (0.021% and 1% w/w) of a biodegradable polymer on soil chemical and microbiological properties over a year.
View Article and Find Full Text PDFArticle Synopsis
- Inflammatory bowel disease (IBD) is a chronic digestive disorder with no cure, consisting mainly of ulcerative colitis and Crohn's disease, leading to significant health challenges and reduced quality of life.
- Current treatments focus on managing symptoms rather than addressing the root causes, highlighting the need for new, effective therapies.
- Bromodomain-containing protein 4 (BRD4) is being studied as a potential therapeutic target, with promising results from inhibitors showing anti-inflammatory effects in lab tests and mouse models, paving the way for future drug development.