[The results of surgical treatment of critical leg ischemia in dependence on wound microbial flora].

The results of treatment of 82 patients with critical lower limbs ischemia were analyzed. All patients had throphic ulcers and gangrene of one or few foot fingers. The study demonstrated the strong correlation between the type of wound microbial flora, distal vessel lesion extetion, type of the arterial reconstruction and limb 1-year survival results.

[Surgical mistakes in treatment of patients with lower limbs' critical ischemia].

The immediate and long-term results of the operative treatment of 473 patients with lower limbs' critical ischemia were analyzed. The ischemia was caused by vascular damage under the level of Pupart ligament. All patients overcame direct and indirect surgical revascularization procedures.

[Effect of tactical errors on outcomes of surgical management of patients with lower limb critical ischaemia].

The review contains the analysis of the literature dedicated to the problem of surgical treatment of patients presenting with lower limb critical ischaemia, followed by consideration of errors and their effect on the outcomes of both direct and indirect revascularizing operations in lesions of the femoropoplietal-tibial segment.

[Inhibition of alkaline phosphatase by thioureido derivatives of methylenebisphosphonic acid].

A series of thioureido derivatives of methylenebisphosphonic acid were synthesized by the reaction of aminomethylenebisphosphonic acid with the corresponding isothiocyanates, and their effect on the activity of alkaline phosphatases from bovine small intestine mucosa (BSIM) and human placenta was studied. It was found that (3-phenylthioureido)methylenebisphosphonate is approximately one order of magnitude more effective in inhibiting the activity of alkaline phosphatase from BSIM than the alkyl derivatives of thioureidomethylenebisphosphonic acid with methyl, ethyl, tert-butyl, or cyclohexyl substituents. The introduction of substituents into the benzene ring of (3-phenylthioureido)methylenebisphosphonate decreased the effect of the inhibitor on the activity of the enzyme.